Fig. 1

Behavioral characterization at several time points following IB4-saporin injection. a Assessment of mechanical allodynia using von Frey filaments in IB4-saporin-treated and sham animals; mechanical thresholds were not significantly different from the sham group. b Assessment of mechanical hyperalgesia using pin prick in IB4-saporin-injected and sham groups; there was no significant difference in mechanical nociceptive rating between IB4-saporin-injected and sham groups. c Assessment of thermal hyperalgesia using the Hargreaves test in IB4-saporin-injected and sham groups; IB4-saporin-injected animals did not display a significant difference in withdrawal latencies at any of the time points studied following IB4-saporin injection when compared with the sham group. N = 6, two-way ANOVA with Bonferroni post hoc