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Fig. 5 | Molecular Pain

Fig. 5

From: Anoctamin-1 Cl− channels in nociception: activation by an N-aroylaminothiazole and capsaicin and inhibition by T16A[inh]-A01

Fig. 5

ANO1-inhibitor attenuates mouse nocifensive behavior responses to capsaicin. The average number (a) and time spent in (b) nocifensive behavior responses (licks, flicks, lifts and total responses) by mice hind paws (n = 8) to subplantar injections of 50 µM capsaicin (Cap black bar) were significantly more than subplantar injections of an Ano1-inhibitor 1.3 mM T16A[inh]-A01 mixed with 50 µM capsaicin (Cap + Ano1-inh, white bar) in contralateral paws, (pre-treated injection was given 2 h earlier with 1.3 mM Ano1-inh). c Average total time spent performing nocifensive behaviors at each minute increment (1-hrough 5th minute following injection of capsaicin (Cap black bar) or Ano1-inh mixed with capsaicin (Cap + Ano1-inh, white bar), as described for (b). All nocifensive behaviors were quantified from videos of the 5 min. immediately following subplantar injections. Injection regimens occurred on different days and opposite paws of the same mice. Error bars are SE. (***p > 0.001, **p > 0.01, *p > 0.05)

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Molecular Pain

ISSN: 1744-8069

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