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Fig. 6 | Molecular Pain

Fig. 6

From: Sympathetic fibre sprouting in the skin contributes to pain-related behaviour in spared nerve injury and cuff models of neuropathic pain

Fig. 6

Sympathetic fibres do not sprout in the DRG of cuff and SNI animals. a Bar graph showing the percentage of cells in close proximity to a DBH-IR sympathetic fibre in the DRG at 2 and 6 weeks after cuff and SNI. b Photomicrograph showing representative DBH-IR fibres in the DRG of a 6 week cuff rat. Note that while sympathetic fibres can be seen within the DRG, they are not in close contact with cell bodies and the pattern of staining is no different in sham animals. c TH and DBH immunoreactivities were fully colocalized in sympathetic fibres in the DRG; this micrograph shows a rare TH-IR (green) + DBH-IR (red) sympathetic fibre within the DRG in close proximity to a cell body in a 6 week cuff rat. For quantitative purposes n = 3–4 per group. Scale bar 50 µm

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