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Fig. 1 | Molecular Pain

Fig. 1

From: Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons

Fig. 1

Simplified model of resurgent current generation (adapted from Cannon, 2010 [79]). Resurgent current is proposed to be generated by open-channel block mechanism. As VGSCs open upon depolarization (+30 mV), the open-channel blocker (represented as red sphere) competes with the intrinsic mechanism of inactivation (intracellular between DIII and DIV, represented by the yellow sphere). Binding of the open-channel blocker terminates transient sodium current but prevents the channel from inactivating forcing the channel to remain in an open-blocked state. Membrane repolarization (−40 mV for example) causes the blocker to unbind from the channel in the open-blocked state and resurgence of sodium conductance occurs (i.e. resurgent current). Unbinding of the blocker allows channels to return to closed state directly or as they recover from subsequent classic inactivation

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