Fig. 4
From: Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons
Navβ4 knockdown reduces endogenous fast resurgent current. Representative traces of endogenous fast resurgent currents obtained from medium-large diameter DRG neurons cultured from rats injected with n.t. control (a) or β4siRNA (b). Peak resurgent current traces are highlighted with black (n.t. control) and brown (β4siRNA). c Compared with n.t. control, β4siRNA significantly decreased the percentage of DRG neurons that generated resurgent currents (p < 0.0005, χ2 test). d Compared to control (black squares, n = 19), Navβ4 knockdown (brown diamonds, n = 20) significantly decreased resurgent current amplitude in a range of voltages. (*p < 0.05 obtained from Student’s t test). Note that resurgent currents were normalized to peak transient currents and plotted as a function of voltage. Summary data are mean ± SEM