Table 1 Parameters of human Nav1.6r transient currents with beta subunit co-expression
From: Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons
Activation | Inactivation | Current density (nA/pF) | |||
|---|---|---|---|---|---|
V1/2 (mV) | k | V1/2 (mV) | k | ||
Control n | −41.1 ± 1.7 34 | 5.3 ± 0.3 34 | −76.2 ± 1.3 35 | 6.2 ± 0.1 35 | 2.1 ± 0.4 36 |
Navβ2 n | −46.0 ± 2.5 15 | 4.2 ± 0.3* 15 | −77.1 ± 2.5 15 | 7.2 ± 0.2# 15 | 2.3 ± 0.4 15 |
Navβ4-WT n | −42.4 ± 1.8 24 | 5.9 ± 0.4 24 | −72.3 ± 1.8* 21 | 6.0 ± 0.1 21 | 1.0 ± 0.2* 24 |
Navβ4-Mt n | −30.5 ± 1.9#,† 16 | 5.7 ± 0.3 16 | −67.1 ± 1.7#,† 16 | 8.3 ± 0.5#,† 16 | 1.3 ± 0.3 16 |