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Fig. 4 | Molecular Pain

Fig. 4

From: Transient, activity dependent inhibition of transmitter release from low threshold afferents mediated by GABAA receptors in spinal cord lamina III/IV

Fig. 4

Glycine receptors do not contribute to presynaptic inhibition of transmitter release. a Example of the effects of 300 nM strychnine and strychnine plus 10 μM gabazine on a train of four eEPSCs recorded from a lamina III/IV neuron (averaged eEPSCs from 5 to 6 consecutive traces in each condition). b Mean EPSC peak amplitudes in control, strychnine and strychnine plus gabazine are plotted for each of the four synaptic events, from a sample of seven lamina III/IV neurons. While strychnine alone is not effective, addition of gabazine causes a significant increase of the second peak (repeated measures ANOVA, Tukey post-test, p < 0.05, n = 7). c The increase of the eEPSC second peak in gabazine is related to PPRctl, as shown in Fig. 3

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Molecular Pain

ISSN: 1744-8069

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