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Fig. 9 | Molecular Pain

Fig. 9

From: Transient, activity dependent inhibition of transmitter release from low threshold afferents mediated by GABAA receptors in spinal cord lamina III/IV

Fig. 9

Afferent driven release of GABA onto low threshold afferent terminals can suppress strong excitatory drive in dorsal horn circuitry. a EPSCs evoked by strong excitatory drive (i.e., a four stimuli train in our experiments) causes strong depression of the second EPSC. b When GABAA-mediated presynaptic inhibition is absent, as is thought to occur in some chronic pain states, the strong depression on the second EPSC is relieved and the overall level of excitability in dorsal horn circuits is increased

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Molecular Pain

ISSN: 1744-8069

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