MicroRNA circulating in the early aftermath of motor vehicle collision predict persistent pain development and suggest a role for microRNA in sex-specific pain differences

Table 3 Association of Emergency Department expression levels of microRNA (miRNA) from the X chromosome with persistent axial pain following motor vehicle collision in women vs. men and assessment of interaction between sex of an individual and miRNA

miRNA	Women (n = 31)		Men (n = 22)		Interaction (sex × miRNA)
miRNA	Fold difference	P value^a	Fold difference	P value^a	P value^b
miR-502-3p	2.17	0.001	1.17	0.562	0.400
miR-500a-3p	1.39	0.009	1.36	0.300	0.251
miR-501-5p	−1.41	0.037	1.45	0.217	0.071
miR-362-5p	1.32	0.049	1.55	0.151	0.030
miR-20b-5p	1.47	0.012	1.12	0.847	0.878
miR-500b-5p	2.60	0.014	−1.36	0.606	0.054
Let-7f-2-3p	6.9	0.001	−2.06	0.797	0.015
miR-532-5p	1.24	0.093	1.41	0.243	0.294

^ap values were calculated using the Mann–Whitney U test
^bp values for the interaction term were calculated using a logistic regression model adjusted for age and site. P values meeting a significance threshold of p <0.05 are italicized

ISSN: 1744-8069