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Table 3 Regions in which treatment-related changes in connectivity (pre-treatment 6–pre-treatment 1) were positively correlated with change in clinical KOOS pain (post–pre)

From: The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients

Clinical outcome

ICA networks

Area

Z value

Peak coordinate

KOOS change in pain

Right frontoparietal network

Left anterior insula

4.06

−34, 30, 8

Left posterior insula/left posterior parietal operculum

2.9

−52, −32, 20

Left putamen

3.94

−28, −10, −8

Left superior temporal/left mid temporal gyrus

4.02

−50, −52, 20

Left parahippocampus

3.32

−34, −32, −18

Cerebellum

4.39

18, −48, −38

Executive control network

Right mid frontal gyrus

3.99

38, 20, 32

Sensory-motor network

None

None

None