Fig. 2
Oxaliplatin administration increases TRPA1 mRNA and protein in DRGs. a Effect of oxaliplatin (6 mg/kg, i.p.) on TRPA1 mRNA expression in rat DRGs (L4–6) at days 0 (before administration), 1, 2, 4, and 7 was measured. TRPA1 expression was normalized to β-actin expression. Histograms show the relative amount of TRPA1 mRNA in oxaliplatin-treated rats compared with day 0. Data are the mean ± SEM. n = 4 for oxaliplatin administration. *P < 0.05, **P < 0.01 versus day 0. b Effect of oxaliplatin (6 mg/kg, i.p.) on TRPA1 protein expression in rat DRGs (L4–6). TRPA1 and β-actin protein in DRGs at days 0 (before administration), 1, 2, 4, and 7 was measured. TRPA1 expression was normalized to β-actin expression. Histograms show the relative amount of TRPA1 protein in oxaliplatin-treated rats. The western blot shows representative data. Data are the mean ± SEM. n = 4 each for 5 % glucose and oxaliplatin administration. *P < 0.05, **P < 0.01 versus day 0