Fig. 1

Activation of neuronal p38 reduces the expression of P2X3R. a Pre-treatment of DRGs with Anis (10 nM, 1 h) significantly reduced the P2X3R expression in DRGs [Anis/Con, 0.72 ± 0.04, n(Con) = 5, n(Anis) = 8]. Treating DRGs with both FC (100 µM) and Anis did not alter the inhibitory action of Anis on P2X3R expression [(Anis + FC)/Con = 0.74 ± 0.07 (mean ± SEM), n(Con) = 5, n(Anis + FC) = 6]. b Pre-treatment of DRGs with Anis (10 nM, 1 h) did not alter the P2X7R expression [Anis/Con, 1.15 ± 0.05, n(Con) = 4, n(Anis) = 3)]. c Treating DRGs with the JNK inhibitor, SP600125 (SP) (2 µM) did not change the P2X3R expression [SP/Con = 0.93 ± 0.13 n(Con) = 4, n(SP) = 3]. *P < 0.05 compared with Con; NS not significant, P > 0.05