Skip to main content
Fig. 3 | Molecular Pain

Fig. 3

From: p38 MAPK mediates glial P2X7R-neuronal P2Y1R inhibitory control of P2X3R expression in dorsal root ganglion neurons

Fig. 3

P2X7R and P2Y1R regulate pp38 expression. a Inhibition of P2X7R or P2Y1R activity reduces pp38 expression. Treating DRGs with the P2X7R antagonist, oxATP (100 µM), or with the P2Y1R antagonist, MRS2179 (60 µM) for 3 h greatly diminished the expression of pp38 (oxATP/Con, 0.16 ± 0.10; MRS/Con, 0.39 ± 0.10, n = 3, *P < 0.05). b Incubation of DRGs with the specific P2X7R antagonist A740003 (A74) also decreased the pp38 expression [(A740003/Con, 0.42 ± 0.08, n (Con) = 9, n(740003) = 7, *P < 0.05]. c (Left) Treating DRGs with the P2YR agonist, 2mesADP (100 µM), increased the pp38 expression (2mesADP/Con = 1.53 ± 0.11,*P < 0.05). (right) Incubation of the P2Y1R antagonist, MRS, with 2mesADP blocked the enhancing effect of 2mesADP on pp38 expression (Con/2mesADP + MRS, 1.05 ± 0.08, n = 3, NS, P > 0.05)

Back to article page