Fig. 1
Loss of Nav1.9 does not influence orofacial sensitivity in mice. Mechanical orofacial sensitivity in response to 0.04 g von Frey filament applied to the forehead (a) and thermal orofacial sensitivity in response to radiant heat applied to a vibrissal pad (b) in sham-operated Nav1.9+/+ and Nav1.9−/− mice. Mechanical (c) and thermal (d) orofacial sensitivities baselines. Mechanical (e) and thermal (f) orofacial sensitivities evaluated before (pre) and at different time-points after surgery. Changes in mechanical (g) and thermal (h) orofacial sensitivities after sham-operation. Values represent mean ± SEM analysed for 13–14 mice. **p < 0.01, ***p < 0.001 compared to that before surgery (pre) (Student paired t test)