Fig. 2

Orofacial neuropathic hypersensitivity was attenuated in Na_v1.9 KO mice. Changes in mechanical orofacial sensitivity in response to 0.04 g von Frey filament applied to the forehead (a) and thermal orofacial sensitivity in response to radiant heat applied to a ipsilateral vibrissal pad (b) in Na_v1.9^+/+ and Na_v1.9^−/− mice before surgery (pre) and at different time-point after CION. Values represent mean ± SEM. analysed for 13–14 mice. *p < 0.05, **p < 0.01, ***p < 0.001 compared to the correspondent time-point in sham Na_v1.9^+/+ mice (Two-way ANOVA followed by Bonferroni’s test)