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Fig. 3 | Molecular Pain

Fig. 3

From: Short-term pre- and post-operative stress prolongs incision-induced pain hypersensitivity without changing basal pain perception

Fig. 3

Effect of post-surgical exposure to short-term immobilization on post-surgical pain in male rats. a, b Mechanical stimuli. c, d Heat stimuli. e Cold stimuli. a, c, e Responses of ipsilateral (incision-stressed) paws. b, d Responses of contralateral paws. Post-surgical exposure to short-term immobilization markedly delayed recovery of paw withdrawal threshold to mechanical stimulation (a) and paw withdrawal latency to heat (c) on days 7 and 9 post-immobilization and paw withdrawal latency to cold (e) stimuli on days 4, 7, and 9 post-immobilization on the ipsilateral side in the incision plus immobilization group compared to the incision plus control group. The sham plus control and the sham plus immobilization groups showed no changes in paw withdrawal responses during the observation period. Mean ± SEM. *P < 0.05, **P < 0.01 vs the corresponding time points in the incision plus control group. N = 5/group

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Molecular Pain

ISSN: 1744-8069

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