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Fig. 4 | Molecular Pain

Fig. 4

From: Short-term pre- and post-operative stress prolongs incision-induced pain hypersensitivity without changing basal pain perception

Fig. 4

Effect of post-surgical exposure to short-term immobilization on post-surgical pain in female rats. a, b Mechanical stimuli. c, d Heat stimuli. e Cold stimuli. a, c, e Responses of ipsilateral (incision-stressed) paws. b, d Responses of contralateral paws. Post-surgical exposure to short-term immobilization markedly delayed recovery of paw withdrawal threshold to mechanical stimulation (a) and paw withdrawal latencies to heat (c) and cold (e) stimuli on days 7 and 9 post-immobilization on the ipsilateral side in the incision plus immobilization group, compared to the incision plus control group. No changes in paw withdrawal responses were seen during the observation period in the sham plus control and sham plus immobilization groups. Mean ± SEM. *P < 0.05, **P < 0.01 vs the corresponding time points in the incision plus control group. N = 5/group

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Molecular Pain

ISSN: 1744-8069

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