Skip to main content
Fig. 8 | Molecular Pain

Fig. 8

From: Short-term pre- and post-operative stress prolongs incision-induced pain hypersensitivity without changing basal pain perception

Fig. 8

Effect of bilateral adrenalectomy (ADX) on exacerbated post-surgical pain induced by short-term immobilization stress. a, b Mechanical stimuli. c, d Heat stimuli. e Cold stimuli. a, c, e Responses of ipsilateral paws. b, d Responses of contralateral paws. In the incision plus immobilization group, sham surgery of ADX (sham-ADX) before immobilization showed marked reductions in paw withdrawal threshold to mechanical stimulation (a) and paw withdrawal latencies to heat (c) and cold (e) stimuli on the ipsilateral side on day 9 post-incision. Bilateral ADX before immobilization entirely reversed these reductions (a, c, e). ADX and sham ADX showed similar paw withdrawal responses to mechanical, heat, and cold stimuli on the contralateral sides of all groups (b, d). ADX and sham ADX did not affect the responses of the ipsilateral paws to the stimuli (a, c, e) of the sham-incision plus control group, the incision plus control group, and the sham-incision plus immobilization group. Mean ± SEM. **P < 0.01 vs the corresponding sham-incision plus control group with sham-ADX. N = 5/group. Im immobilization

Back to article page