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  1. Neuropathic pain caused by peripheral nerve injury is a chronic disorder that represents a significant clinical challenge because the pathological mechanisms have not been fully elucidated. Several studies hav...

    Authors: Devang Kashyap Thakor, Audrey Lin, Yoshizo Matsuka, Edward M Meyer, Supanigar Ruangsri, Ichiro Nishimura and Igor Spigelman

    Citation: Molecular Pain 2009 5:14

    Content type: Research

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  2. Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain. Specifically, low COMT activity is associated with heightened pain perceptio...

    Authors: Inna E Tchivileva, Andrea G Nackley, Li Qian, Sean Wentworth, Matthew Conrad and Luda B Diatchenko

    Citation: Molecular Pain 2009 5:13

    Content type: Research

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  3. ATP-sensitive potassium (KATP) channels in neurons regulate excitability, neurotransmitter release and mediate protection from cell-death. Furthermore, activation of KATP channels is suppressed in DRG neurons aft...

    Authors: Takashi Kawano, Vasiliki Zoga, Masakazu Kimura, Mei-Ying Liang, Hsiang-En Wu, Geza Gemes, J Bruce McCallum, Wai-Meng Kwok, Quinn H Hogan and Constantine D Sarantopoulos

    Citation: Molecular Pain 2009 5:12

    Content type: Research

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  4. Although the systemic administration of cannabinoids produces antinociception, their chronic use leads to analgesic tolerance as well as cross-tolerance to morphine. These effects are mediated by cannabinoids ...

    Authors: Javier Garzón, Elena de la Torre-Madrid, María Rodríguez-Muñoz, Ana Vicente-Sánchez and Pilar Sánchez-Blázquez

    Citation: Molecular Pain 2009 5:11

    Content type: Research

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  5. Cisplatin has been in use for 40 years for treatment of germ line and other forms of cancer. Oxaliplatin is approved for treatment of metastatic colorectal cancer. Thirty to forty percent of cancer patients re...

    Authors: Lauren E Ta, Philip A Low and Anthony J Windebank

    Citation: Molecular Pain 2009 5:9

    Content type: Methodology

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  6. Neuropathic pain (NP) is partially mediated by neuroinflammatory mechanisms, and also modulates local neurogenic inflammation. Dietary lipids, in particular the total amount and relative proportions of polyuns...

    Authors: Yasmina B Martin and Carlos Avendaño

    Citation: Molecular Pain 2009 5:8

    Content type: Research

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  7. Nerve injury-triggered hyperexcitability in primary sensory neurons is considered a major source of chronic neuropathic pain. The hyperexcitability, in turn, is thought to be related to transcriptional switchi...

    Authors: Anna-Karin Persson, Mathias Gebauer, Suzana Jordan, Christiane Metz-Weidmann, Anke M Schulte, Hans-Christoph Schneider, Danping Ding-Pfennigdorff, Jonas Thun, Xiao-Jun Xu, Zsuzsanna Wiesenfeld-Hallin, Ariel Darvasi, Kaj Fried and Marshall Devor

    Citation: Molecular Pain 2009 5:7

    Content type: Research

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  8. Nerve injury-induced expression of the spinal calcium channel alpha-2-delta-1 subunit (Cavα2δ1) has been shown to mediate behavioral hypersensitivity through a yet identified mechanism. We examined if this neurop...

    Authors: David Nguyen, Ping Deng, Elizabeth A Matthews, Doo-Sik Kim, Guoping Feng, Anthony H Dickenson, Zao C Xu and Z David Luo

    Citation: Molecular Pain 2009 5:6

    Content type: Research

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  9. Transient receptor potential Vanilloid (TRPV) receptors are involved in nociception and are expressed predominantly in sensory neurons. TRPV1, a non-selective cation channel has been extensively studied and is...

    Authors: De-Shou Cao, Shuang-Quan Yu and Louis S Premkumar

    Citation: Molecular Pain 2009 5:5

    Content type: Research

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  10. Abundantly expressed in pain-sensing neurons, TRPV1, TRPA1 and TRPM8 are major cellular sensors of thermal, chemical and mechanical stimuli. The function of these ion channels has been attributed to their sele...

    Authors: Jun Chen, Donghee Kim, Bruce R Bianchi, Eric J Cavanaugh, Connie R Faltynek, Philip R Kym and Regina M Reilly

    Citation: Molecular Pain 2009 5:3

    Content type: Research

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  11. Glycine receptors (GlyRs) play important roles in regulating hippocampal neural network activity and spinal nociception. Here we show that, in cultured rat hippocampal (HIP) and spinal dorsal horn (SDH) neuron...

    Authors: Peng Jiang, Yan Kong, Xiao-Bing Zhang, Wei Wang, Chun-Feng Liu and Tian-Le Xu

    Citation: Molecular Pain 2009 5:2

    Content type: Research

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  12. Inflammation-mediated hyperalgesia involves tissue acidosis and sensitization of nociceptors. Many studies have reported increased expression of acid-sensing ion channel 3 (ASIC3) in inflammation and enhanced ...

    Authors: Yi-Tin Yen, Pan-Hsien Tu, Chien-Ju Chen, Yi-Wen Lin, Sung-Tsang Hsieh and Chih-Cheng Chen

    Citation: Molecular Pain 2009 5:1

    Content type: Research

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  13. Spinal cord α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) mediate acute spinal processing of nociceptive and non-nociceptive information, but whether and how their activation contribu...

    Authors: Jang-Su Park, Myron Yaster, Xiaowei Guan, Ji-Tian Xu, Ming-Hung Shih, Yun Guan, Srinivasa N Raja and Yuan-Xiang Tao

    Citation: Molecular Pain 2008 4:67

    Content type: Research

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  14. Adenosine 5'-triphosphate (ATP) has a ubiquitous role in metabolism and a major role in pain responses after tissue injury. We investigated the changes in basal and KCl-evoked ATP release from rat dorsal root ...

    Authors: Yoshizo Matsuka, Takeshi Ono, Hirotate Iwase, Somsak Mitrirattanakul, Kevin S Omoto, Ting Cho, Yan Yan N Lam, Bradley Snyder and Igor Spigelman

    Citation: Molecular Pain 2008 4:66

    Content type: Research

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  15. The glial glutamate transporter GLT-1 is abundantly expressed in astrocytes and is crucial for glutamate removal from the synaptic cleft. Decreases in glutamate uptake activity and expression of spinal glutama...

    Authors: Sanae Maeda, Ai Kawamoto, Yumi Yatani, Hisashi Shirakawa, Takayuki Nakagawa and Shuji Kaneko

    Citation: Molecular Pain 2008 4:65

    Content type: Research

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  16. Genetic variation contributes to differences in pain sensitivity and response to different analgesics. Catecholamines are involved in the modulation of pain and are partly metabolized by the catechol-O-methylt...

    Authors: Trude T Rakvåg, Joy R Ross, Hiroe Sato, Frank Skorpen, Stein Kaasa and Pål Klepstad

    Citation: Molecular Pain 2008 4:64

    Content type: Research

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  17. Cytokines such as interleukin 1β (IL-1β) have been implicated in the development of central sensitization that is characteristic of neuropathic pain. To examine its long-term effect on nociceptive processing, ...

    Authors: Sabrina L Gustafson-Vickers, Van B Lu, Aaron Y Lai, Kathryn G Todd, Klaus Ballanyi and Peter A Smith

    Citation: Molecular Pain 2008 4:63

    Content type: Research

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  18. The role of the neurotrophin regulated polypeptide, VGF, has been investigated in a rat spared injury model of neuropathic pain. This peptide has been shown to be associated with synaptic strengthening and lea...

    Authors: Andrew Moss, Rachel Ingram, Stephanie Koch, Andria Theodorou, Lucie Low, Mark Baccei, Gareth J Hathway, Michael Costigan, Stephen R Salton and Maria Fitzgerald

    Citation: Molecular Pain 2008 4:62

    Content type: Research

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  19. The present study aims to investigate the role of transient receptor potential vanilloid 1 (TRPV1) in dorsal root ganglion (DRG) neurons in chronic pain including thermal hyperalgesia and mechanical allodynia....

    Authors: Lu Yu, Fei Yang, Hao Luo, Feng-Yu Liu, Ji-Sheng Han, Guo-Gang Xing and You Wan

    Citation: Molecular Pain 2008 4:61

    Content type: Research

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  20. EphB receptor tyrosine kinases, which play important roles in synaptic connection and plasticity during development and in matured nervous system, have recently been implicated in processing of pain after nerv...

    Authors: Yuan Han, Xue-Song Song, Wen-Tao Liu, Mark Henkemeyer and Xue-Jun Song

    Citation: Molecular Pain 2008 4:60

    Content type: Research

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  21. In order to evaluate mechanisms that may underlie the sensitization of trigeminal spinal subnucleus caudalis (Vc; the medullary dorsal horn) and upper cervical spinal cord (C1-C2) nociceptive neurons to heat, ...

    Authors: Kuniya Honda, Junichi Kitagawa, Barry J Sessle, Masahiro Kondo, Yoshiyuki Tsuboi, Yoshiyuki Yonehara and Koichi Iwata

    Citation: Molecular Pain 2008 4:59

    Content type: Research

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  22. Pain is often a dominant clinical feature of chronic pancreatitis but the frequency and severity is highly variable between subjects. We hypothesized that genetic polymorphisms contribute to variations in clin...

    Authors: Mark Lazarev, Janette Lamb, M Michael Barmada, Feng Dai, Michelle A Anderson, Mitchell B Max and David C Whitcomb

    Citation: Molecular Pain 2008 4:58

    Content type: Research

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  23. Pain is a major symptom associated with chronic inflammation. In previous work from our laboratory, we have shown that in animal models of neuropathic pain there is a sprouting of sympathetic fibers into the u...

    Authors: Lina Almarestani, Geraldine Longo and Alfredo Ribeiro-da-Silva

    Citation: Molecular Pain 2008 4:56

    Content type: Short report

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  24. Recently, increasing evidence has indicated that the primary acupuncture effects are mediated by the central nervous system. However, specific brain networks underpinning these effects remain unclear.

    Authors: Wei Qin, Jie Tian, Lijun Bai, Xiaohong Pan, Lin Yang, Peng Chen, Jianping Dai, Lin Ai, Baixiao Zhao, Qiyong Gong, Wei Wang, Karen M von Deneen and Yijun Liu

    Citation: Molecular Pain 2008 4:55

    Content type: Research

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  25. There is evidence to suggest that the midbrain periaqueductal grey (PAG) has a role in migraine and the actions of the anti-migraine drug sumatriptan. In the present study we examined the serotonergic modulati...

    Authors: Hyo-Jin Jeong, David Chenu, Emma E Johnson, Mark Connor and Christopher W Vaughan

    Citation: Molecular Pain 2008 4:54

    Content type: Research

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  26. Besides functioning as chemosensors for a broad range of endogenous and synthetic ligands, transient receptor potential vanilloid (TRPV) 1–4 channels have also been related to capsaicin (TRPV1), pain, and ther...

    Authors: Giacomo Spinsanti, Raffaella Zannolli, Cristina Panti, Ilaria Ceccarelli, Letizia Marsili, Valeria Bachiocco, Francesco Frati and Anna Maria Aloisi

    Citation: Molecular Pain 2008 4:51

    Content type: Research

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  27. Cutaneous tactile allodynia, or painful hypersensitivity to mechanical stimulation of the skin, is typically associated with neuropathic pain, although also present in chronic pain patients who do not have evi...

    Authors: Andre Laferrière, Magali Millecamps, Dimitris N Xanthos, Wen Hua Xiao, Chiang Siau, Marissa de Mos, Christelle Sachot, J Vaigunda Ragavendran, Frank JPM Huygen, Gary J Bennett and Terence J Coderre

    Citation: Molecular Pain 2008 4:49

    Content type: Research

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  28. Safe and effective treatment for chronic inflammatory and neuropathic pain remains a key unmet medical need for many patients. The recent discovery and description of the transient receptor potential family of...

    Authors: Samer R Eid, Eric D Crown, Eric L Moore, Hongyu A Liang, Kar-Chan Choong, Shelley Dima, Darrell A Henze, Stefanie A Kane and Mark O Urban

    Citation: Molecular Pain 2008 4:48

    Content type: Research

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  29. The effects of an analgesic treatment (lidocaine patches) on brain activity in chronic low back pain (CBP) and in knee osteoarthritis (OA) were investigated using serial fMRI (contrasting fMRI between before a...

    Authors: Marwan N Baliki, Paul Y Geha, Rami Jabakhanji, Norm Harden, Thomas J Schnitzer and A Vania Apkarian

    Citation: Molecular Pain 2008 4:47

    Content type: Research

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  30. Lysophosphatidic acid receptor subtype LPA1 is crucial for the initiation of neuropathic pain and underlying changes, such as up-regulation of Ca2+ channel α2δ-1 subunit in dorsal root ganglia (DRG), up-regulatio...

    Authors: Weijiao Xie, Misaki Matsumoto, Jerold Chun and Hiroshi Ueda

    Citation: Molecular Pain 2008 4:46

    Content type: Short report

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  31. Postsynaptic density (PSD)-93, a neuronal scaffolding protein, binds to and clusters N-methyl-D-aspartate receptor (NMDAR) subunits NR2A and NR2B at cellular membranes in vitro. However, the roles of PSD-93 in sy...

    Authors: Wen-Jinn Liaw, Xu-Guang Zhu, Myron Yaster, Roger A Johns, Estelle B Gauda and Yuan-Xiang Tao

    Citation: Molecular Pain 2008 4:45

    Content type: Research

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  32. NMDA receptors are important elements in pain signaling in the spinal cord dorsal horn. They are heterotetramers typically composed of two NR1 and two of four NR2 subunits: NR2A-2D. Mice lacking specific NR2 s...

    Authors: Chi-Kun Tong, Edward J Kaftan and Amy B MacDermott

    Citation: Molecular Pain 2008 4:44

    Content type: Research

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  33. Rodent models of orofacial pain typically use methods adapted from manipulations to hind paw; however, limitations of these models include animal restraint and subjective assessments of behavior by the experim...

    Authors: John K Neubert, Christopher King, Wendi Malphurs, Fong Wong, James P Weaver, Alan C Jenkins, Heather L Rossi and Robert M Caudle

    Citation: Molecular Pain 2008 4:43

    Content type: Research

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  34. The capsaicin receptor, known as transient receptor potential channel vanilloid subtype 1 (TRPV1), is activated by a wide range of noxious stimulants and putative ligands such as capsaicin, heat, pH, anandamid...

    Authors: Dong Ho Woo, Sung Jun Jung, Mei Hong Zhu, Chul-Kyu Park, Yong Ho Kim, Seog Bae Oh and C Justin Lee

    Citation: Molecular Pain 2008 4:42

    Content type: Research

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  35. Mice lacking the preproenkephalin (ppENK) gene are hyperalgesic and show more anxiety and aggression than wild-type (WT) mice. The marked behavioral changes in ppENK knock-out (KO) mice appeared to occur in supra...

    Authors: Tsung-Chieh Chen, Ying-Ying Cheng, Wei-Zen Sun and Bai-Chuang Shyu

    Citation: Molecular Pain 2008 4:41

    Content type: Research

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  36. Both presynaptic and postsynaptic alterations are associated with plastic changes of brain circuits, such as learning and memory, drug addiction and chronic pain. However, the dissection of the relative contri...

    Authors: Long-Jun Wu, Hendrik W Steenland, Susan S Kim, Carolina Isiegas, Ted Abel, Bong-Kiun Kaang and Min Zhuo

    Citation: Molecular Pain 2008 4:40

    Content type: Research

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  37. The effects of GABA, excitatory amino-acid receptors antagonists and a glial metabolism inhibitor on primary-afferent excitation in the spinal dorsal horn were studied by imaging the presynaptic excitation of ...

    Authors: Hiroshi Ikeda, Takaki Kiritoshi and Kazuyuki Murase

    Citation: Molecular Pain 2008 4:39

    Content type: Research

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  38. Altered Na+ channel expression, enhanced excitability, and spontaneous activity occur in nerve-injury and inflammatory models of pathological pain, through poorly understood mechanisms. The cytokine GRO/KC (growt...

    Authors: Jun-Gang Wang, Judith A Strong, Wenrui Xie, Rui-Hua Yang, Dennis E Coyle, Dayna M Wick, Ericka D Dorsey and Jun-Ming Zhang

    Citation: Molecular Pain 2008 4:38

    Content type: Research

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  39. Paroxysmal extreme pain disorder (PEPD) is an autosomal dominant painful neuropathy with many, but not all, cases linked to gain-of-function mutations in SCN9A which encodes voltage-gated sodium channel Nav1.7. S...

    Authors: Sulayman D Dib-Hajj, Mark Estacion, Brian W Jarecki, Lynda Tyrrell, Tanya Z Fischer, Mark Lawden, Theodore R Cummins and Stephen G Waxman

    Citation: Molecular Pain 2008 4:37

    Content type: Research

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  40. Altered Cl- homeostasis and GABAergic function are associated with nociceptive input hypersensitivity. This study investigated the role of two major intracellular Cl- regulatory proteins, Na+-K+-Cl- cotransporter...

    Authors: Samuel W Cramer, Christopher Baggott, John Cain, Jessica Tilghman, Bradley Allcock, Gurwattan Miranpuri, Sharad Rajpal, Dandan Sun and Daniel Resnick

    Citation: Molecular Pain 2008 4:36

    Content type: Research

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  41. Regulation of pain states is, in part, dependent upon plastic changes in neurones within the superficial dorsal horn. There is also compelling evidence that pain states are under the control of descending proj...

    Authors: Sandrine M Géranton, Vincenza Fratto, Keri K Tochiki and Stephen P Hunt

    Citation: Molecular Pain 2008 4:35

    Content type: Research

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  42. Expectation is a very potent pain modulator in both humans and animals. There is evidence that pain transmission neurons are modulated by expectation preceding painful stimuli. Nonetheless, few studies have ex...

    Authors: Jin-Yan Wang, Han-Ti Zhang, Jing-Yu Chang, Donald J Woodward, Luiz A Baccalá and Fei Luo

    Citation: Molecular Pain 2008 4:34

    Content type: Research

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  43. Neuropathic pain may arise following peripheral nerve injury though the molecular mechanisms associated with this are unclear. We used proteomic profiling to examine changes in protein expression associated wi...

    Authors: Hong-Lei Huang, Cruz-Miguel Cendan, Carolina Roza, Kenji Okuse, Rainer Cramer, John F Timms and John N Wood

    Citation: Molecular Pain 2008 4:33

    Content type: Research

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  44. Chloride currents in peripheral nociceptive neurons have been implicated in the generation of afferent nociceptive signals, as Cl- accumulation in sensory endings establishes the driving force for depolarizing, a...

    Authors: Katharina Funk, Anne Woitecki, Christina Franjic-Würtz, Thomas Gensch, Frank Möhrlen and Stephan Frings

    Citation: Molecular Pain 2008 4:32

    Content type: Research

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