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  1. The peptide neurotransmitter N-Acetylaspartylglutamate (NAAG) is the third most prevalent transmitter in the mammalian central nervous system. Local, intrathecal and systemic administration of inhibitors of enzym...

    Authors: Tatsuo Yamamoto, Alan Kozikowski, Jia Zhou and Joseph H Neale

    Citation: Molecular Pain 2008 4:31

    Content type: Research

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  2. A number of prostaglandins (PGs) sensitize dorsal root ganglion (DRG) neurons and contribute to inflammatory hyperalgesia by signaling through specific G protein-coupled receptors (GPCRs). One mechanism whereb...

    Authors: Lillian Cruz-Orengo, Ajay Dhaka, Robert J Heuermann, Timothy J Young, Michael C Montana, Eric J Cavanaugh, Donghee Kim and Gina M Story

    Citation: Molecular Pain 2008 4:30

    Content type: Research

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  3. Itch is one of the major complications of skin diseases. Although there are various substances that induce itch or pruritus, it is evident that histamine is the best known endogenous agent that evokes itch. Ev...

    Authors: Won-Sik Shim and Uhtaek Oh

    Citation: Molecular Pain 2008 4:29

    Content type: Review

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  4. The pathogenic role of brain derived neurotrophic factor (BDNF) in the incisional pain is poorly understood. The present study explores the role of the BDNF in the incision-induced pain hypersensitivity.

    Authors: Chang-Qi Li, Jun-Mei Xu, Dan Liu, Jian-Yi Zhang and Ru-Ping Dai

    Citation: Molecular Pain 2008 4:27

    Content type: Research

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  5. The laterocapsular division of the central nucleus of the amygdala (CeLC) has emerged as an important site of pain-related plasticity and pain modulation. Glutamate and neuropeptide receptors in the CeLC contr...

    Authors: Yu Fu, Jeong Han, Titilope Ishola, Michelle Scerbo, Hita Adwanikar, Cara Ramsey and Volker Neugebauer

    Citation: Molecular Pain 2008 4:26

    Content type: Research

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  6. We have previously demonstrated that different spinal transmissions are involved in the nociceptive behavior caused by electrical stimulation of Aβ-, Aδ- or C-fibers using a Neurometer® in naïve mice. In this stu...

    Authors: Misaki Matsumoto, Weijiao Xie, Lin Ma and Hiroshi Ueda

    Citation: Molecular Pain 2008 4:25

    Content type: Research

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  7. Pain is comprised of the sensory and affective components. Compared to the well-investigated mechanisms of the sensory pain, much less is known about the mechanisms underlying the affective pain. In recent yea...

    Authors: Yan-Gang Sun, Yong-Jing Gao, Zhong-Qiu Zhao, Bing Huang, Jun Yin, Gregory A Taylor and Zhou-Feng Chen

    Citation: Molecular Pain 2008 4:23

    Content type: Research

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  8. Breathing cold air without proper temperature exchange can induce strong respiratory autonomic responses including cough, airway constriction and mucosal secretion, and can exacerbate existing asthma condition...

    Authors: Hong Xing, Jennifer X Ling, Meng Chen, Richard D Johnson, Makoto Tominaga, Cong-Yi Wang and Jianguo Gu

    Citation: Molecular Pain 2008 4:22

    Content type: Research

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  9. Recent evidence suggests that oxytocin (OT), secreted in the superficial spinal cord dorsal horn by descending axons of paraventricular hypothalamic nucleus (PVN) neurons, produces antinociception and analgesi...

    Authors: Jean-Didier Breton, Pierre Veinante, Sandra Uhl-Bronner, Angela Maria Vergnano, Marie José Freund-Mercier, Rémy Schlichter and Pierrick Poisbeau

    Citation: Molecular Pain 2008 4:19

    Content type: Research

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  10. Honeybee's sting on human skin can induce ongoing pain, hyperalgesia and inflammation. Injection of bee venom (BV) into the intraplantar surface of the rat hindpaw induces an early onset of spontaneous pain fo...

    Authors: Xiu-Yu Cui, Yi Dai, Sheng-Lan Wang, Hiroki Yamanaka, Kimiko Kobayashi, Koichi Obata, Jun Chen and Koichi Noguchi

    Citation: Molecular Pain 2008 4:17

    Content type: Research

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  11. Animal studies and a few human studies have shown a change in sodium channel (NaCh) expression after inflammatory lesions, and this change is implicated in the generation of pain states. We are using the extra...

    Authors: Songjiang Luo, Griffin M Perry, S Rock Levinson and Michael A Henry

    Citation: Molecular Pain 2008 4:16

    Content type: Research

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  12. Neuronal plasticity along the pathway for sensory transmission including the spinal cord and cortex plays an important role in chronic pain, including inflammatory and neuropathic pain. While recent studies in...

    Authors: Fuxing Zhang, Kujumon I Vadakkan, Susan S Kim, Long-Jun Wu, Yuze Shang and Min Zhuo

    Citation: Molecular Pain 2008 4:15

    Content type: Research

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  13. Animals detect environmental changes through sensory neural mechanisms that enable them to differentiate the quality, intensity and temporal characteristics of stimuli. The 'doctrine of specific nervous energi...

    Authors: Carlos Belmonte and Félix Viana

    Citation: Molecular Pain 2008 4:14

    Content type: Review

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  14. Understanding differences in the genetic architecture of complex traits between the two sexes has significant implications for evolutionary studies and clinical diagnosis. However, our knowledge about sex-spec...

    Authors: Chenguang Wang, Yun Cheng, Tian Liu, Qin Li, Roger B Fillingim, Margaret R Wallace, Roland Staud, Lee Kaplan and Rongling Wu

    Citation: Molecular Pain 2008 4:13

    Content type: Methodology

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  15. The aberrant release of the neurotransmitters, glutamate and calcitonin-gene related peptide (CGRP), from trigeminal neurons has been implicated in migraine. The voltage-gated P/Q-type calcium channel has a cr...

    Authors: Yan Xiao, Judith A Richter and Joyce H Hurley

    Citation: Molecular Pain 2008 4:12

    Content type: Short report

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  16. Although a variety of industrial chemicals, as well as several chemotherapeutic agents used to treat cancer or HIV, preferentially induce a peripheral sensory neuropathy what remains unclear is why these agent...

    Authors: Juan M Jimenez-Andrade, Monica B Herrera, Joseph R Ghilardi, Marina Vardanyan, Ohannes K Melemedjian and Patrick W Mantyh

    Citation: Molecular Pain 2008 4:10

    Content type: Research

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  17. A common complication associated with diabetes is painful or painless diabetic peripheral neuropathy (DPN). The mechanisms and determinants responsible for these peripheral neuropathies are poorly understood. ...

    Authors: Reddy M Pabbidi, Shuang-Quan Yu, Siying Peng, Romesh Khardori, Mary E Pauza and Louis S Premkumar

    Citation: Molecular Pain 2008 4:9

    Content type: Research

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  18. A chronic pancreatitis model was developed in young male Lewis rats fed a high-fat and alcohol liquid diet beginning at three weeks. The model was used to assess time course and efficacy of a replication defec...

    Authors: Hong Yang, Terry A McNearney, Rong Chu, Ying Lu, Yong Ren, David C Yeomans, Steven P Wilson and Karin N Westlund

    Citation: Molecular Pain 2008 4:8

    Content type: Research

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  19. The chronic use of opioids prior to surgery leads to lowered pain thresholds and exaggerated pain levels after these procedures. Several mechanisms have been proposed to explain this heightened sensitivity com...

    Authors: DeYong Liang, Xiaoyou Shi, Yanli Qiao, Martin S Angst, David C Yeomans and J David Clark

    Citation: Molecular Pain 2008 4:7

    Content type: Research

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  20. Recently, we reported that lysophosphatidic acid (LPA) induces long-lasting mechanical allodynia and thermal hyperalgesia as well as demyelination and upregulation of pain-related proteins through one of its c...

    Authors: Makoto Inoue, Lin Ma, Junken Aoki, Jerold Chun and Hiroshi Ueda

    Citation: Molecular Pain 2008 4:6

    Content type: Short report

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  21. Glutamate receptors of the AMPA type (AMPArs) mediate fast excitatory transmission in the dorsal horn and are thought to underlie perception of both acute and chronic pain. They are tetrameric structures made ...

    Authors: Erika Polgár, Masahiko Watanabe, Bettina Hartmann, Seth GN Grant and Andrew J Todd

    Citation: Molecular Pain 2008 4:5

    Content type: Research

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  22. Over the past three years Molecular Pain has grown steadily and clearly demonstrated its ability to publish novel scientific discoveries in the field of pain research in a timely fashion, hence having a strong...

    Authors: Min Zhuo and Jianguo Gu

    Citation: Molecular Pain 2008 4:4

    Content type: Editorial

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  23. Resiniferatoxin (RTX) is an ultrapotent capsaicin analog that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1). There is a large body of evidence supporting a role for TR...

    Authors: John K Neubert, Andrew J Mannes, Laszlo J Karai, Alan C Jenkins, Lanel Zawatski, Mones Abu-Asab and Michael J Iadarola

    Citation: Molecular Pain 2008 4:3

    Content type: Research

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  24. The orphan GPCR MrgE is one of an extended family of GPCRs that are expressed in dorsal root ganglia (DRG). Based on these expression patterns it has been suggested that GPCRs like MrgE may play a role in nocicep...

    Authors: Peter J Cox, Tom Pitcher, Steven A Trim, Christine H Bell, Wenning Qin and Ross A Kinloch

    Citation: Molecular Pain 2008 4:2

    Content type: Short report

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  25. Primary erythromelalgia is an autosomal dominant pain disorder characterized by burning pain and skin redness in the extremities, with onset of symptoms during the first decade in the families whose mutations ...

    Authors: Xiaoyang Cheng, Sulayman D Dib-Hajj, Lynda Tyrrell and Stephen G Waxman

    Citation: Molecular Pain 2008 4:1

    Content type: Short report

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  26. Although substance P (SP) is an important primary afferent modulator in nociceptive processes, it is unclear whether SP regulates its own release from primary sensory neurons.

    Authors: He-Bin Tang, Yu-Sang Li, Koji Arihiro and Yoshihiro Nakata

    Citation: Molecular Pain 2007 3:42

    Content type: Research

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  27. We have proposed that nerve injury-specific loss of spinal tonic cholinergic inhibition may play a role in the analgesic effects of nicotinic acetylcholine receptor (nAChR) agonists on neuropathic pain. Howeve...

    Authors: Misaki Matsumoto, Weijiao Xie, Makoto Inoue and Hiroshi Ueda

    Citation: Molecular Pain 2007 3:41

    Content type: Research

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  28. Mechanical hyperalgesia is a clinically-relevant form of pain sensitization that develops through largely unknown mechanisms. TRPA1, a Transient Receptor Potential ion channel, is a sensor of pungent chemicals...

    Authors: Matt Petrus, Andrea M Peier, Michael Bandell, Sun Wook Hwang, Truc Huynh, Nicholas Olney, Tim Jegla and Ardem Patapoutian

    Citation: Molecular Pain 2007 3:40

    Content type: Research

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  29. Agonists of TRPA1 such as mustard oil and its key component AITC cause pain and neurogenic inflammation in humans and pain behavior in rodents. TRPA1 is activated by numerous reactive compounds making it a sen...

    Authors: Lana Klionsky, Rami Tamir, BaoXi Gao, Weiya Wang, David C Immke, Nobuko Nishimura and Narender R Gavva

    Citation: Molecular Pain 2007 3:39

    Content type: Research

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  30. Animal and clinical studies have revealed that focal peripheral nerve axon demyelination is accompanied by nociceptive pain behavior. C-C and C-X-C chemokines and their receptors have been strongly implicated ...

    Authors: Sonia Bhangoo, Dongjun Ren, Richard J Miller, Kenneth J Henry, Jayana Lineswala, Chafiq Hamdouchi, Baolin Li, Patrick E Monahan, David M Chan, Matthew S Ripsch and Fletcher A White

    Citation: Molecular Pain 2007 3:38

    Content type: Research

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  31. Long-term potentiation (LTP) in the anterior cingulate cortex (ACC) is believed to be critical for higher brain functions including emotion, learning, memory and chronic pain. N-methyl-D-aspartate (NMDA) recep...

    Authors: Hiroki Toyoda, Ming-Gao Zhao, Hui Xu, Long-Jun Wu, Ming Ren and Min Zhuo

    Citation: Molecular Pain 2007 3:36

    Content type: Research

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  32. Endothelin-1 (ET-1) both stimulates nociceptors and sensitizes them to noxious stimuli, an effect probably mediated by the ETA receptor (ETAR) expressed in sensory neurons. The cellular mechanisms of this ET-1-me...

    Authors: Tim D Plant, Christian Zöllner, Frauke Kepura, Shaaban S Mousa, Jenny Eichhorst, Michael Schaefer, Jens Furkert, Christoph Stein and Alexander Oksche

    Citation: Molecular Pain 2007 3:35

    Content type: Research

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  33. A 53-year old woman with tic doloureaux, affecting her right maxillary division of the trigeminal nerve (V2), could elicit shooting pains by slightly tapping her teeth when off medication. The pains, which she...

    Authors: David Borsook, Eric A Moulton, Gautam Pendse, Susie Morris, Sadie H Cole, Matthew Aiello-Lammens, Steven Scrivani and Lino R Becerra

    Citation: Molecular Pain 2007 3:34

    Content type: Research

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  34. Accumulating evidence over last several years indicates an important role of microglial cells in the pathogenesis of neuropathic pain. Signal transduction in microglia under chronic pain states has begun to be...

    Authors: Ru-Rong Ji and Marc R Suter

    Citation: Molecular Pain 2007 3:33

    Content type: Review

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  35. Persistent pain produces complex alterations in sensory pathways of the central nervous system (CNS) through activation of various nociceptive mechanisms. However, the effects of pain on higher brain centers, ...

    Authors: Vanja Duric and Kenneth E McCarson

    Citation: Molecular Pain 2007 3:32

    Content type: Research

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  36. Inflammatory mediators can directly sensitize primary afferent nociceptors to mechanical and osmotic stimuli. Sensitized nociceptors have a lowered threshold of activation and increased spontaneous activity, w...

    Authors: Xiaojie Chen, Nicole Alessandri-Haber and Jon D Levine

    Citation: Molecular Pain 2007 3:31

    Content type: Research

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  37. Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV1) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexe...

    Authors: Qing Lin, Dingge Li, Xijin Xu, Xiaoju Zou and Li Fang

    Citation: Molecular Pain 2007 3:30

    Content type: Research

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  38. Neuronal nitric oxide synthase (nNOS) is a key enzyme for nitric oxide production in neuronal tissues and contributes to the spinal central sensitization in inflammatory pain. However, the role of nNOS in neur...

    Authors: Yun Guan, Myron Yaster, Srinivasa N Raja and Yuan-Xiang Tao

    Citation: Molecular Pain 2007 3:29

    Content type: Research

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  39. Inflammation and nociceptive sensitization are hallmarks of tissue surrounding surgical incisions. Recent studies demonstrate that several cytokines may participate in the enhancement of nociception near these...

    Authors: J David Clark, Xiaoyou Shi, Xiangqi Li, Yanli Qiao, DeYong Liang, Martin S Angst and David C Yeomans

    Citation: Molecular Pain 2007 3:28

    Content type: Research

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  40. Disinhibition of neurons in the superficial spinal dorsal horn, via microglia – neuron signaling leading to disruption of chloride homeostasis, is a potential cellular substrate for neuropathic pain. But, a ce...

    Authors: A Florence Keller, Simon Beggs, Michael W Salter and Yves De Koninck

    Citation: Molecular Pain 2007 3:27

    Content type: Research

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  41. Somatosensory information can be modulated by nicotinic acetylcholine receptors (nAChRs) in the superficial dorsal horn of the spinal cord. Nonetheless, the functional significance of nAChRs in the deep dorsal...

    Authors: Daisuke Takeda, Terumasa Nakatsuka, Jianguo G Gu and Munehito Yoshida

    Citation: Molecular Pain 2007 3:26

    Content type: Research

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  42. An understanding of how the brain changes in chronic pain or responds to pharmacological or other therapeutic interventions has been significantly changed as a result of developments in neuroimaging of the CNS...

    Authors: David Borsook, Eric A Moulton, Karl F Schmidt and Lino R Becerra

    Citation: Molecular Pain 2007 3:25

    Content type: Review

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  43. While cannabinoid receptor agonists have analgesic activity in inflammatory pain states they produce a range of side effects. Recently, it has been demonstrated that the arachidonic acid-amino acid conjugate, ...

    Authors: Rebecca Succar, Vanessa A Mitchell and Christopher W Vaughan

    Citation: Molecular Pain 2007 3:24

    Content type: Short report

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