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  1. Gastrin-releasing peptide (GRP) and its receptor have been shown to play an important role in the sensation of itch. However, although GRP immunoreactivity has been detected in the spinal dorsal horn, there is...

    Authors: Maria Gutierrez-Mecinas, Masahiko Watanabe and Andrew J Todd

    Citation: Molecular Pain 2014 10:79

    Content type: Research

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  2. Neuropathic pain is believed to be influenced in part by inflammatory processes. In this study we examined the effect of variability in the C-type lectin gene cluster (Aplec) on the development of neuropathic ...

    Authors: Cecilia A Dominguez, Karl E Carlström, Xing-Mei Zhang, Faiez Al Nimer, Rickard P F Lindblom, Andre Ortlieb Guerreiro-Cacais and Fredrik Piehl

    Citation: Molecular Pain 2014 10:78

    Content type: Research

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  3. T-type calcium channels and cannabinoid receptors are known to play important roles in chronic pain, making them attractive therapeutic targets. We recently reported on the design, synthesis and analgesic prop...

    Authors: N Daniel Berger, Vinicius M Gadotti, Ravil R Petrov, Kevin Chapman, Philippe Diaz and Gerald W Zamponi

    Citation: Molecular Pain 2014 10:77

    Content type: Research

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  4. Recent studies have suggested an association between genotypes affecting the expression of the serotonin transporter and thermal pain perception and the thermal grill. The aim of this study was to investigate ...

    Authors: Ellen Lund Schaldemose, Emilia Horjales-Araujo, Ditte Demontis, Anders D Børglum, Peter Svensson and Nanna Brix Finnerup

    Citation: Molecular Pain 2014 10:76

    Content type: Research

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  5. The P2X7 receptor is a member of the P2X family of adenosine 5′-triphosphate-gated cation channels. Several recent studies have demonstrated that this receptor is involved in mechanisms related to pain and inflam...

    Authors: Soichiro Ide, Daisuke Nishizawa, Ken-ichi Fukuda, Shinya Kasai, Junko Hasegawa, Masakazu Hayashida, Masabumi Minami and Kazutaka Ikeda

    Citation: Molecular Pain 2014 10:75

    Content type: Research

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  6. The perception of painful thermal stimuli by sensory neurons is largely mediated by TRPV1. Upon tissue injury or inflammation, S1P is secreted by thrombocytes as part of an inflammatory cocktail, which sensiti...

    Authors: Michiel Langeslag, Serena Quarta, Michael G Leitner, Michaela Kress and Norbert Mair

    Citation: Molecular Pain 2014 10:74

    Content type: Research

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  7. Histone deacetylases (HDACs) and histone acetyltransferases (HATs) are key players in epigenetic regulation of gene expression. Analgesic activity by HDAC inhibitors has been reported in different pain models ...

    Authors: Magda Zammataro, Maria Angela Sortino, Carmela Parenti, Robert W Gereau IV and Santina Chiechio

    Citation: Molecular Pain 2014 10:68

    Content type: Short report

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  8. Chronic Pancreatitis (CP) is a complex and multifactorial syndrome. Many contributing factors result in development of dysfunctional pain in a significant number of patients. Drugs developed to treat a variety...

    Authors: Liping Zhang, Robert H Kline IV, Terry A McNearney, Michael P Johnson and Karin N Westlund

    Citation: Molecular Pain 2014 10:66

    Content type: Research

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  9. Long-term potentiation (LTP) is a key cellular mechanism for pathological pain in the central nervous system. LTP contains at least two different phases: early-phase LTP (E-LTP) and late-phase LTP (L-LTP). Amo...

    Authors: Tao Chen, Gerile O’Den, Qian Song, Kohei Koga, Ming-Ming Zhang and Min Zhuo

    Citation: Molecular Pain 2014 10:65

    Content type: Research

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  10. The current pharmacological treatments for chronic pain are limited. The first analgesic drug approved for clinical use in decades that has a novel molecular target is the synthetic version of a naturally occu...

    Authors: Sarasa Mohammadi and Macdonald J Christie

    Citation: Molecular Pain 2014 10:64

    Content type: Research

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  11. Gabapentin (GBP) is known to suppress neuropathic hypersensitivity of primary afferents and the spinal cord dorsal horn. However, its supra-spinal action sites are unclear. We identify the brain regions where ...

    Authors: Hsiao-Chun Lin, Yu-Hsin Huang, Tzu-Hao Harry Chao, Wen-Ying Lin, Wei-Zen Sun and Chen-Tung Yen

    Citation: Molecular Pain 2014 10:63

    Content type: Research

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  12. Intraplantar administration of complete Freund's adjuvant (CFA) and formalin are two noxious stimuli commonly used to produce sustained pain-related behaviors in rodents for research on neurobiology and treatm...

    Authors: Michael D Leitl, David N Potter, Kejun Cheng, Kenner C Rice, William A Carlezon Jr and S Stevens Negus

    Citation: Molecular Pain 2014 10:62

    Content type: Research

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  13. This study aimed to evaluate the prophylactic effect of goshajinkigan (GJG) on paclitaxel (PTX)-induced neuropathy and to elucidate the mechanism of action.

    Authors: Yukiko Matsumura, Yoshihito Yokoyama, Hachidai Hirakawa, Tatsuhiko Shigeto, Masayuki Futagami and Hideki Mizunuma

    Citation: Molecular Pain 2014 10:61

    Content type: Research

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  14. Genetic polymorphisms, gender and age all influence the risk of developing chronic neuropathic pain following peripheral nerve injury (PNI). It is known that there are significant inter-strain differences in p...

    Authors: Lindsay S Cahill, Christine L Laliberté, Xue Jun Liu, Jonathan Bishop, Brian J Nieman, Jeffrey S Mogil, Robert E Sorge, Catherine D Jones, Michael W Salter and R Mark Henkelman

    Citation: Molecular Pain 2014 10:60

    Content type: Research

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  15. Lumbar radicular pain is categorized as a type of neuropathic pain, but its pathophysiological mechanisms are not fully understood. The substantia gelatinosa (SG) in the spinal cord dorsal horn receives primar...

    Authors: Tsuyoshi Miyakawa, Yoshinori Terashima, Tsuneo Takebayashi, Katsumasa Tanimoto, Takehito Iwase, Izaya Ogon, Takeshi Kobayashi, Noritsugu Tohse and Toshihiko Yamashita

    Citation: Molecular Pain 2014 10:58

    Content type: Research

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  16. Inhibitory interneurons are an important component of dorsal horn circuitry where they serve to modulate spinal nociception. There is now considerable evidence indicating that reduced inhibition in the spinal ...

    Authors: Louis-Etienne Lorenzo, Claire Magnussen, Andrea L Bailey, Manon St Louis, Yves De Koninck and Alfredo Ribeiro-da-Silva

    Citation: Molecular Pain 2014 10:57

    Content type: Research

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  17. Cisplatin, a platinum-derived chemotherapeutic agent, produces antineoplastic effects coupled with toxic neuropathic pain and impaired general health status. These side-effects complicate long term studies of ...

    Authors: Josée Guindon, Liting Deng, Baochang Fan, Jim Wager-Miller and Andrea G Hohmann

    Citation: Molecular Pain 2014 10:56

    Content type: Research

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  18. Real-time quantitative PCR (qPCR) is a technique frequently used to measure changes in mRNA expression. To ensure validity of experimental findings, it is important to normalize the qPCR data to reference gene...

    Authors: Roxanne Y Walder, Anne-Sophie Wattiez, Stephanie R White, Blanca Marquez de Prado, Marta V Hamity and Donna L Hammond

    Citation: Molecular Pain 2014 10:55

    Content type: Research

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  19. Gene therapy with adeno-associated virus (AAV) has advanced in the last few years from promising results in animal models to >100 clinical trials (reported or under way). While vector availability was a substa...

    Authors: Josef Pleticha, Lukas F Heilmann, Christopher H Evans, Aravind Asokan, Richard Jude Samulski and Andreas S Beutler

    Citation: Molecular Pain 2014 10:54

    Content type: Review

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  20. Paclitaxel is an effective chemotherapeutic agent widely used for the treatment of solid tumors. The major dose-limiting toxicity of paclitaxel is peripheral neuropathy. The mechanisms underlying the developme...

    Authors: Ryutaro Ochi-ishi, Kenichiro Nagata, Tomoyuki Inoue, Hidetoshi Tozaki-Saitoh, Makoto Tsuda and Kazuhide Inoue

    Citation: Molecular Pain 2014 10:53

    Content type: Research

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  21. Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator with a unique cyclic phosphate ring at the sn-2 and sn-3 positions of its glycerol backbone. Natural cPA and its chemically stabilized...

    Authors: Mari Gotoh, Aya Nagano, Ryoko Tsukahara, Hiromu Murofushi, Toshiro Morohoshi, Kazuyuki Otsuka and Kimiko Murakami-Murofushi

    Citation: Molecular Pain 2014 10:52

    Content type: Research

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  22. Three neuropeptides, gastrin releasing peptide (GRP), natriuritic precursor peptide B (NPPB), and neuromedin B (NMB) have been proposed to play roles in itch sensation. However, the tissues in which these pept...

    Authors: Samridhi C Goswami, Danielle Thierry-Mieg, Jean Thierry-Mieg, Santosh Mishra, Mark A Hoon, Andrew J Mannes and Michael J Iadarola

    Citation: Molecular Pain 2014 10:44

    Content type: Short report

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  23. Despite advances in understanding the signaling mechanisms involved in the development and maintenance of chronic pain, the pharmacologic treatment of chronic pain has seen little advancement. Agonists at the ...

    Authors: Matthew P Rowan, Kalina Szteyn, Allison P Doyle, Ruben Gomez, Michael A Henry and Nathaniel A Jeske

    Citation: Molecular Pain 2014 10:50

    Content type: Research

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  24. HIV-associated sensory neuropathy affects over 50% of HIV patients and is a common peripheral nerve complication of HIV infection and highly active antiretroviral therapy (HAART). Evidence shows that painful H...

    Authors: Wenwen Zheng, Wan Huang, Shue Liu, Roy C Levitt, Keith A Candiotti, David A Lubarsky and Shuanglin Hao

    Citation: Molecular Pain 2014 10:49

    Content type: Research

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  25. Opioid analgesics are the most effective drugs for the treatment of moderate to severe pain. However, they also produce several adverse effects that can complicate pain management. The μ opioid (MOP) receptor,...

    Authors: Tanila Ben Haddou, Davide Malfacini, Girolamo Calo, Mario D Aceto, Louis S Harris, John R Traynor, Andrew Coop, Helmut Schmidhammer and Mariana Spetea

    Citation: Molecular Pain 2014 10:48

    Content type: Research

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  26. The molecular mechanisms underlying neuropathic pain are constantly being studied to create new opportunities to prevent or alleviate neuropathic pain. The aim of our study was to determine the gene expression...

    Authors: Ewelina Rojewska, Michal Korostynski, Ryszard Przewlocki, Barbara Przewlocka and Joanna Mika

    Citation: Molecular Pain 2014 10:47

    Content type: Research

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  27. Fibromyalgia (FM) is conceptualized as a central sensitization (CS) condition, that presents high serum brain-derived neurotrophic factor (BDNF) and neuroglia activation. Although the S100B protein regulates n...

    Authors: Simone Azevedo Zanette, Jairo Alberto Dussan-Sarria, Andressa Souza, Alicia Deitos, Iraci Lucena Silva Torres and Wolnei Caumo

    Citation: Molecular Pain 2014 10:46

    Content type: Research

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  28. Transcriptional regulation of genes by cyclic AMP response element binding protein (CREB) is essential for the maintenance of long-term memory. Moreover, retrograde axonal trafficking of CREB in response to ne...

    Authors: Ohannes K Melemedjian, Dipti V Tillu, Jamie K Moy, Marina N Asiedu, Edward K Mandell, Sourav Ghosh, Gregory Dussor and Theodore J Price

    Citation: Molecular Pain 2014 10:45

    Content type: Research

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  29. Prolonged intracellular calcium elevation contributes to sensitization of nociceptors and chronic pain in inflammatory conditions. The underlying molecular mechanisms remain unknown but store-operated calcium ...

    Authors: Hazim Alkhani, Ariel R Ase, Rebecca Grant, Dajan O’Donnell, Klaus Groschner and Philippe Séguéla

    Citation: Molecular Pain 2014 10:43

    Content type: Research

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  30. Painful Diabetic Neuropathy (PDN) is a debilitating syndrome present in a quarter of diabetic patients that has a substantial impact on their quality of life. Despite this significant prevalence and impact, cu...

    Authors: Daniela Maria Menichella, Belmadani Abdelhak, Dongjun Ren, Andrew Shum, Caroline Frietag and Richard J Miller

    Citation: Molecular Pain 2014 10:42

    Content type: Research

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  31. Recently we showed that unilateral peripheral neuropathic lesions impacted differentially on rat’s emotional/cognitive behavior depending on its left/right location; importantly, this observation recapitulates...

    Authors: Hugo Leite-Almeida, Marco Rafael Guimarães, João José Cerqueira, Nuno Ribeiro-Costa, Helena Anjos-Martins, Nuno Sousa and Armando Almeida

    Citation: Molecular Pain 2014 10:41

    Content type: Short report

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  32. Tissue acidosis is effective in causing chronic muscle pain. However, how muscle nociceptors contribute to the transition from acute to chronic pain is largely unknown.

    Authors: Wei-Nan Chen, Cheng-Han Lee, Shing-Hong Lin, Chia-Wen Wong, Wei-Hsin Sun, John N Wood and Chih-Cheng Chen

    Citation: Molecular Pain 2014 10:40

    Content type: Research

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  33. Descending control of nociceptive processing, by pathways originating in the rostral ventromedial medulla (RVM) and terminating in the dorsal horn, contributes to behavioural hypersensitivity in a number of pa...

    Authors: Fiona B Carr, Sandrine M Géranton and Stephen P Hunt

    Citation: Molecular Pain 2014 10:39

    Content type: Research

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  34. Thyroid hormones are essential for the maturation and functions of the central nervous system. Pain sensitivity is related to the thyroid status. However, information on how thyroid hormones affect pain proces...

    Authors: Jun Yi, Jian-yong Zheng, Wei Zhang, Shan Wang, Zhi-fu Yang and Ke-feng Dou

    Citation: Molecular Pain 2014 10:38

    Content type: Research

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  35. Genetic causes of exaggerated or reduced pain sensitivity in humans are well known. Recently, single nucleotide polymorphisms (SNPs) in the gene P2RX7, coding for the ATP-gated ion channel P2X7, have been describ...

    Authors: Daniel Ursu, Philip Ebert, Emily Langron, Cara Ruble, Leanne Munsie, Wei Zou, Bonnie Fijal, Yue-Wei Qian, Terry A McNearney, Adrian Mogg, Olivera Grubisha, Kalpana Merchant and Emanuele Sher

    Citation: Molecular Pain 2014 10:37

    Content type: Research

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  36. Macrophage infiltration to inflammatory sites promotes wound repair and may be involved in pain hypersensitivity after surgical incision. We recently reported that the development of hyperalgesia during chroni...

    Authors: Kohei Godai, Maiko Hasegawa-Moriyama, Tae Kurimoto, Takayuki Saito, Tomotsugu Yamada, Takahiro Sato, Masayasu Kojima and Yuichi Kanmura

    Citation: Molecular Pain 2014 10:36

    Content type: Research

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  37. It has been recently recognized that the descending serotonin (5-HT) system from the rostral ventromedial medulla (RVM) in the brainstem and the 5-HT3 receptor subtype in the spinal dorsal horn are involved in en...

    Authors: Wei Guo, Kan Miyoshi, Ronald Dubner, Ming Gu, Man Li, Jian Liu, Jiale Yang, Shiping Zou, Ke Ren, Koichi Noguchi and Feng Wei

    Citation: Molecular Pain 2014 10:35

    Content type: Research

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  38. It is well-documented that neonates can experience pain after injury. However, the contribution of individual populations of sensory neurons to neonatal pain is not clearly understood. Here we characterized th...

    Authors: Michael P Jankowski, Jessica L Ross, Jonathon D Weber, Frank B Lee, Aaron T Shank and Renita C Hudgins

    Citation: Molecular Pain 2014 10:34

    Content type: Research

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  39. Long-term potentiation (LTP) is the key cellular mechanism for physiological learning and pathological chronic pain. In the anterior cingulate cortex (ACC), postsynaptic recruitment or modification of AMPA rec...

    Authors: Tao Chen, Kohei Koga, Giannina Descalzi, Shuang Qiu, Jian Wang, Le-Shi Zhang, Zhi-Jian Zhang, Xiao-Bin He, Xin Qin, Fu-Qiang Xu, Ji Hu, Feng Wei, Richard L Huganir, Yun-Qing Li and Min Zhuo

    Citation: Molecular Pain 2014 10:33

    Content type: Research

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  40. Recently discovered neuropeptide S (NPS) has anxiolytic and pain-inhibiting effects in rodents. We showed previously that NPS increases synaptic inhibition of amygdala output to inhibit pain behaviors. The amy...

    Authors: Georgina Medina, Guangchen Ji, Stéphanie Grégoire and Volker Neugebauer

    Citation: Molecular Pain 2014 10:32

    Content type: Research

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  41. Artemin (Artn), a member of the glial cell line-derived growth factor (GDNF) family, supports the development and function of a subpopulation of peptidergic, TRPV1-positive sensory neurons. Artn (enovin, neubl...

    Authors: Kathryn M Albers, Xiu Lin Zhang, Charlotte M Diges, Erica S Schwartz, Charles I Yang, Brian M Davis and Michael S Gold

    Citation: Molecular Pain 2014 10:31

    Content type: Research

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