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  1. The participation of spinal P2X receptors in neuropathic pain is well recognized. However, the role of P2Y receptors has been less studied. The purpose of this study was to investigate the contribution of spin...

    Authors: Paulino Barragán-Iglesias, Jorge Baruch Pineda-Farias, Claudia Cervantes-Durán, Mariana Bravo-Hernández, Héctor Isaac Rocha-González, Janet Murbartián and Vinicio Granados-Soto

    Citation: Molecular Pain 2014 10:29

    Content type: Research

    Published on:

  2. Bone cancer pain is currently a major clinical challenge for the management of cancer patients, and the cellular and molecular mechanisms underlying the spinal sensitization remain unclear. While several studi...

    Authors: Yanju Bao, Wei Hou, Rui Liu, Yebo Gao, Xiangying Kong, Liping Yang, Zhan Shi, Weidong Li, Honggang Zheng, Shulong Jiang, Conghuang Li, Yinggang Qin and Baojin Hua

    Citation: Molecular Pain 2014 10:28

    Content type: Research

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  3. Chemotherapeutic treatment results in chronic pain in an estimated 30-40 percent of patients. Limited and often ineffective treatments make the need for new therapeutics an urgent one. We compared the effects ...

    Authors: Elizabeth J Rahn, Liting Deng, Ganesh A Thakur, Kiran Vemuri, Alexander M Zvonok, Yvonne Y Lai, Alexandros Makriyannis and Andrea G Hohmann

    Citation: Molecular Pain 2014 10:27

    Content type: Research

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  4. Acute and chronic pain in axial structures, like the back and neck, are difficult to treat, and have incidence as high as 15%. Surprisingly, most preclinical work on pain mechanisms focuses on cutaneous struct...

    Authors: Belinda M Harris, David I Hughes, Philip S Bolton, Melissa A Tadros, Robert J Callister and Brett A Graham

    Citation: Molecular Pain 2014 10:25

    Content type: Research

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  5. Recent evidence has shown that the chemerin receptor 23 (ChemR23) represents a novel inflammatory pain target, whereby the ChemR23 agonists, resolvin E1 and chemerin, can inhibit inflammatory pain hypersensiti...

    Authors: Allen C Dickie and Carole Torsney

    Citation: Molecular Pain 2014 10:24

    Content type: Research

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  6. We carried out a genome-wide study, using microRNA sequencing (miRNA-seq), aimed at identifying miRNAs in primary sensory neurons that are associated with neuropathic pain. Such scans usually yield long lists ...

    Authors: Kiran Kumar Bali, Michael Hackenberg, Avigail Lubin, Rohini Kuner and Marshall Devor

    Citation: Molecular Pain 2014 10:22

    Content type: Research

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  7. ATP and P2X receptors play important roles in the modulation of trigeminal neuropathic pain, while the role of G protein-coupled P2Y2 receptors and the underlying mechanisms are less clear. The threshold and freq...

    Authors: Na Li, Zhan-ying Lu, Li-hua Yu, Geoffrey Burnstock, Xiao-ming Deng and Bei Ma

    Citation: Molecular Pain 2014 10:21

    Content type: Research

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  8. Dysregulation of voltage-gated sodium channels (Navs) is believed to play a major role in nerve fiber hyperexcitability associated with neuropathic pain. A complete transcriptional characterization of the differe...

    Authors: Cédric J Laedermann, Marie Pertin, Marc R Suter and Isabelle Decosterd

    Citation: Molecular Pain 2014 10:19

    Content type: Research

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  9. Simultaneous presentation of non-noxious warm (40°C) and cold (20°C) stimuli in an interlacing fashion results in a transient hot burning noxious sensation (matched at 46°C) known as the thermal grill (TG) ill...

    Authors: Albert Leung, Shivshil Shukla, Eric Li, Jeng-Ren Duann and Tony Yaksh

    Citation: Molecular Pain 2014 10:18

    Content type: Research

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  10. The phylogenetically highly conserved CK1 protein kinases consisting of at least seven isoforms form a distinct family within the eukaryotic protein kinases. CK1 family members play crucial roles in a wide ran...

    Authors: Takashi Kurihara, Eri Sakurai, Masayasu Toyomoto, Isao Kii, Daisuke Kawamoto, Toshihide Asada, Tsutomu Tanabe, Megumu Yoshimura, Masatoshi Hagiwara and Atsuro Miyata

    Citation: Molecular Pain 2014 10:17

    Content type: Research

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  11. Citation: Molecular Pain 2014 10:16

    Content type: Erratum

    Published on:

    The original article was published in Molecular Pain 2013 9:33

  12. Refractory chronic pain dramatically reduces the quality of life of patients. Existing drugs cannot fully achieve effective chronic pain control because of their lower efficacy and/or accompanying side effects...

    Authors: Hiroki Hayashi, Masashi Iwata, Noboru Tsuchimori and Tatsumi Matsumoto

    Citation: Molecular Pain 2014 10:15

    Content type: Research

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  13. Affections are thought to regulate pain perception through the descending pain inhibitory system in the central nervous system. In this study, we examined in mice the affective change by inhalation of the lemo...

    Authors: Hiroshi Ikeda, Syuntaro Takasu and Kazuyuki Murase

    Citation: Molecular Pain 2014 10:14

    Content type: Research

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  14. Neuropathic pain is a difficult to treat disorder arising from central or peripheral nervous system lesions. The etiology of neuropathic pain consists of several overlapping pathways converging into an exagger...

    Authors: Maarten Swartjes, Monique van Velzen, Marieke Niesters, Leon Aarts, Michael Brines, Ann Dunne, Anthony Cerami and Albert Dahan

    Citation: Molecular Pain 2014 10:13

    Content type: Research

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  15. Somatostatin (SST) and some of its receptor subtypes have been implicated in pain signaling at the spinal level. In this study we have investigated the role of SST and its sst2A receptor (sst2A) in dorsal root...

    Authors: Tie-Jun Sten Shi, Qiong Xiang, Ming-Dong Zhang, Swapnali Barde, Ylva Kai-Larsen, Kaj Fried, Anna Josephson, Laura Glück, Sergey M Deyev, Andrei V Zvyagin, Stefan Schulz and Tomas Hökfelt

    Citation: Molecular Pain 2014 10:12

    Content type: Research

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  16. Paclitaxel, a widely-used antineoplastic drug, produces a painful peripheral neuropathy that in rodents is associated with peripheral-nerve mitochondrial alterations. The sigma-1 receptor (σ1R) is a ligand-regula...

    Authors: Francisco R Nieto, Cruz M Cendán, Francisco J Cañizares, María A Cubero, José M Vela, Eduardo Fernández-Segura and José M Baeyens

    Citation: Molecular Pain 2014 10:11

    Content type: Research

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  17. Leukocytes containing opioid peptides locally control inflammatory pain. In the early phase of complete Freund’s adjuvant (CFA)-induced hind paw inflammation, formyl peptides (derived e.g. from Mycobacterium buty...

    Authors: Reine-Solange Sauer, Dagmar Hackel, Laura Morschel, Henrike Sahlbach, Ying Wang, Shaaban A Mousa, Norbert Roewer, Alexander Brack and Heike L Rittner

    Citation: Molecular Pain 2014 10:10

    Content type: Research

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  18. Hydrogen sulfide (H2S), an endogenous gaseotransmitter/modulator, is becoming appreciated that it may be involved in a wide variety of processes including inflammation and nociception. However, the role for H2S i...

    Authors: Xiuhua Miao, Xiaowen Meng, Geping Wu, Zhong Ju, Hong-Hong Zhang, Shufen Hu and Guang-Yin Xu

    Citation: Molecular Pain 2014 10:9

    Content type: Research

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  19. Voltage-gated potassium (Kv) channels are critical in controlling neuronal excitability and are involved in the induction of neuropathic pain. Therefore, Kv channels might be potential targets for prevention a...

    Authors: Longchang Fan, Xiaowei Guan, Wei Wang, Jian-Yuan Zhao, Hongkang Zhang, Vinod Tiwari, Paul N Hoffman, Min Li and Yuan-Xiang Tao

    Citation: Molecular Pain 2014 10:8

    Content type: Research

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  20. The past decade has seen an abundance of transcriptional profiling studies of preclinical models of persistent pain, predominantly employing microarray technology. In this study we directly compare exon microa...

    Authors: James R Perkins, Ana Antunes-Martins, Margarita Calvo, John Grist, Werner Rust, Ramona Schmid, Tobias Hildebrandt, Matthias Kohl, Christine Orengo, Stephen B McMahon and David LH Bennett

    Citation: Molecular Pain 2014 10:7

    Content type: Research

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  21. In the present study, we examined spinal glial cell activation as a central nervous system mechanism of widespread mechanical hyperalgesia in rats that experienced chronic post-cast pain (CPCP) 2 weeks after c...

    Authors: Mika Ohmichi, Yusuke Ohmichi, Hitoshi Ohishi, Takahiko Yoshimoto, Atsuko Morimoto, Yuqiang Li, Hiroki Sakurai, Takashi Nakano and Jun Sato

    Citation: Molecular Pain 2014 10:6

    Content type: Research

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  22. Various pathological conditions such as inflammation or injury can evoke pain hypersensitivity. That represents the response to innocuous stimuli or exaggerated response to noxious stimuli. The molecular mecha...

    Authors: Byeongjun Lee, Hawon Cho, Jooyoung Jung, Young Duk Yang, Dong-Jin Yang and Uhtaek Oh

    Citation: Molecular Pain 2014 10:5

    Content type: Research

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  23. A recent study by Mishra and Hoon identified B-type natriuretic peptide (BNP) as an important peptide for itch transmission and proposed that BNP activates spinal natriuretic peptide receptor-A (NPRA) expressi...

    Authors: Xian-Yu Liu, Li Wan, Fu-Quan Huo, Devin M Barry, Hui Li, Zhong-Qiu Zhao and Zhou-Feng Chen

    Citation: Molecular Pain 2014 10:4

    Content type: Short report

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  24. Lamina I projection neurons respond to painful stimuli, and some are also activated by touch or hair movement. Neuropathic pain resulting from peripheral nerve damage is often associated with tactile allodynia...

    Authors: Toshiharu Yasaka, Sheena YX Tiong, Erika Polgár, Masahiko Watanabe, Eiichi Kumamoto, John S Riddell and Andrew J Todd

    Citation: Molecular Pain 2014 10:3

    Content type: Research

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  25. We previously developed a thrombus-induced ischemic pain (TIIP) animal model, which was characterized by chronic bilateral mechanical allodynia without thermal hyperalgesia (TH). On the other hand we had shown...

    Authors: Soon-Gu Kwon, Dae-Hyun Roh, Seo-Yeon Yoon, Ji-Young Moon, Sheu-Ran Choi, Hoon-Seong Choi, Suk-Yun Kang, Ho-Jae Han, Alvin J Beitz, Seog Bae Oh and Jang-Hern Lee

    Citation: Molecular Pain 2014 10:2

    Content type: Research

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  26. Pain in masticatory muscles is among the most prominent symptoms of temperomandibular disorders (TMDs) that have diverse and complex etiology. A common complaint of TMD is that unilateral pain of craniofacial ...

    Authors: Suncana Simonic-Kocijan, Xuehong Zhao, Wen Liu, Yuwei Wu, Ivone Uhac and KeWei Wang

    Citation: Molecular Pain 2013 9:68

    Content type: Research

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  27. Presynaptic voltage-gated calcium CaV2.2 channels play a privileged role in spinal level sensitization following peripheral nerve injury. Direct and indirect inhibitors of CaV2.2 channel activity in spinal dorsal...

    Authors: Yu-Qiu Jiang, Arturo Andrade and Diane Lipscombe

    Citation: Molecular Pain 2013 9:67

    Content type: Research

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  28. Cyclin-dependent kinase 5 (Cdk5) is a unique member of the serine/threonine kinase family. This kinase plays an important role in neuronal development, and deregulation of its activity leads to neurodegenerati...

    Authors: Michaela Prochazkova, Anita Terse, Niranjana D Amin, Bradford Hall, Elias Utreras, Harish C Pant and Ashok B Kulkarni

    Citation: Molecular Pain 2013 9:66

    Content type: Research

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  29. Leptin, an adipocytokine produced mainly by white adipose tissue, has a broad role in the regulation of neuronal functions. Accumulating evidence has revealed that leptin plays an important role in influencing...

    Authors: Xin Li, Lumei Kang, Guilin Li, Huihong Zeng, Lei Zhang, Xiang Ling, Hui Dong, Shangdong Liang and Hongping Chen

    Citation: Molecular Pain 2013 9:65

    Content type: Research

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  30. Our previous work demonstrated that persistent peripheral nociception (PPN) leads to synaptic plasticity and functional changes in the rat hippocampus. The protein kinase mTOR is a critical regulator of protei...

    Authors: Dan Lyu, Wenli Yu, Ning Tang, Ruirui Wang, Zhenyu Zhao, Fang Xie, Yongjin He, Hongyin Du and Jun Chen

    Citation: Molecular Pain 2013 9:64

    Content type: Research

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  31. Phosphorylation sites in the C-terminus of mu-opioid receptors (MORs) are known to play critical roles in the receptor functions. Our understanding of their participation in opioid analgesia is mostly based on...

    Authors: Guangwen Li, Fei Ma, Yanping Gu and Li-Yen Mae Huang

    Citation: Molecular Pain 2013 9:63

    Content type: Research

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  32. ATP-gated P2X3 receptors of sensory ganglion neurons are important transducers of pain as they adapt their expression and function in response to acute and chronic nociceptive signals. The present study invest...

    Authors: Aswini Gnanasekaran, Tanja Bele, Swathi Hullugundi, Manuela Simonetti, Michael D Ferrari, Arn MJM van den Maagdenberg, Andrea Nistri and Elsa Fabbretti

    Citation: Molecular Pain 2013 9:62

    Content type: Short report

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  33. Dopaminergic fibers originating from area A11 of the hypothalamus project to different levels of the spinal cord and represent the major source of dopamine. In addition, tyrosine hydroxylase, the rate-limiting...

    Authors: William Galbavy, Elham Safaie, Mario J Rebecchi and Michelino Puopolo

    Citation: Molecular Pain 2013 9:60

    Content type: Research

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  34. Painful diabetic neuropathy (PDN) is a serious complication of diabetes mellitus that affects a large number of patients in many countries. The molecular mechanisms underlying the exaggerated nociception in PD...

    Authors: Jun Kinoshita, Yukari Takahashi, Ayako M Watabe, Kazunori Utsunomiya and Fusao Kato

    Citation: Molecular Pain 2013 9:59

    Content type: Research

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  35. Voltage gated calcium channels (VGCCs) are well known for its importance in synaptic transmission in the peripheral and central nervous system. However, the role of different VGCCs in the anterior cingulate co...

    Authors: SukJae Joshua Kang, Ming-Gang Liu, Tian-Yao Shi, Ming-Gao Zhao, Bong-Kiun Kaang and Min Zhuo

    Citation: Molecular Pain 2013 9:58

    Content type: Research

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  36. Chronic pain arising from degenerative diseases of the joint such as osteoarthritis (OA) has a strong peripheral component which is likely to be mediator driven. Current treatments which reduce the production ...

    Authors: John M Dawes, Hannes Kiesewetter, James R Perkins, David LH Bennett and Stephen B McMahon

    Citation: Molecular Pain 2013 9:57

    Content type: Research

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  37. Inhibitory interneurons in the superficial dorsal horn play important roles in modulating sensory transmission, and these roles are thought to be performed by distinct functional populations. We have identifie...

    Authors: Noboru Iwagaki, Francesca Garzillo, Erika Polgár, John S Riddell and Andrew J Todd

    Citation: Molecular Pain 2013 9:56

    Content type: Research

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  38. The Gq/11-protein signaling mechanism is essential throughout the nervous system, but little is known about the contribution of the individual G-protein GPCR signaling branches towards nociceptor activation and t...

    Authors: Laura Nikita Wirotanseng, Rohini Kuner and Anke Tappe-Theodor

    Citation: Molecular Pain 2013 9:54

    Content type: Short report

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  39. Oxaliplatin, the third-generation platinum compound, has evolved as one of the most important therapeutic agents in colorectal cancer chemotherapy. The main limiting factor in oxaliplatin treatment is painful ...

    Authors: Maria Isabel Azevedo, Anamaria Falcão Pereira, Ricardo Braz Nogueira, Flávio Esmeraldo Rolim, Gerly AC Brito, Deysi Viviana T Wong, Roberto CP Lima-Júnior, Ronaldo de Albuquerque Ribeiro and Mariana Lima Vale

    Citation: Molecular Pain 2013 9:53

    Content type: Research

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  40. Voltage-gated sodium channels Nav1.8 and Nav1.9 are expressed preferentially in small diameter sensory neurons, and are thought to play a role in the generation of ectopic activity in neuronal cell bodies and/...

    Authors: Emma V Bird, Claire R Christmas, Alison R Loescher, Keith G Smith, Peter P Robinson, Joel A Black, Stephen G Waxman and Fiona M Boissonade

    Citation: Molecular Pain 2013 9:52

    Content type: Research

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  41. Antagonists of N-type voltage-gated calcium channels (VGCC), Cav2.2, can manage severe chronic pain with intrathecal use and may be effective systemically. A series of novel ω-conotoxins that selectively inhibit ...

    Authors: Mahsa Sadeghi, Swetha S Murali, Richard J Lewis, Paul F Alewood, Sarasa Mohammadi and MacDonald J Christie

    Citation: Molecular Pain 2013 9:51

    Content type: Research

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  42. The mammalian target of rapamycin (mTOR) is known to regulate cell proliferation and growth by controlling protein translation. Recently, it has been shown that mTOR signaling pathway is involved in long-term ...

    Authors: Feng Jiang, Xue-Yan Pang, Qing-Shan Niu, Li-Ming Hua, Ming Cheng and Yong-Hua Ji

    Citation: Molecular Pain 2013 9:50

    Content type: Research

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  43. The trigeminal subnuclei interpolaris/caudalis transition zones (Vi/Vc) play an important role in orofacial deep pain, however, the role of primary afferent projections to the Vi/Vc remains to be determined. T...

    Authors: Mamoru Takeda, Masayuki Takahashi, Junichi Kitagawa, Takuya Kanazawa, Masanori Nasu and Shigeji Matsumoto

    Citation: Molecular Pain 2013 9:49

    Content type: Research

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