Skip to main content

Articles

Page 5 of 16

  1. Cancer-associated pain is a major cause of poor quality of life in cancer patients and is frequently resistant to conventional therapy. Recent studies indicate that some hematopoietic growth factors, namely gr...

    Authors: Kiran Kumar Bali, Varun Venkataramani, Venkata P Satagopam, Pooja Gupta, Reinhard Schneider and Rohini Kuner

    Citation: Molecular Pain 2013 9:48

    Content type: Research

    Published on:

  2. The sigma-1 receptor (σ1R), an endoplasmic reticulum chaperone protein, is widely distributed and regulates numerous intracellular processes in neurons. Nerve injury alters the structure and function of axotom...

    Authors: Madhavi L Bangaru, Dorothee Weihrauch, Qing-Bo Tang, Vasiliki Zoga, Quinn Hogan and Hsiang-en Wu

    Citation: Molecular Pain 2013 9:47

    Content type: Research

    Published on:

  3. Multiple protein kinases affect the responses of dorsal horn neurons through phosphorylation of synaptic receptors and proteins involved in intracellular signal transduction pathways, and the consequences of t...

    Authors: Yun Wang, Yongzhong Lei, Li Fang, Yonggao Mu, Jing Wu and Xuan Zhang

    Citation: Molecular Pain 2013 9:46

    Content type: Review

    Published on:

  4. The metabotropic glutamate receptor 7 (mGluR7) negative allosteric modulator, 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP), was locally microinjected into the ventrolate...

    Authors: Enza Palazzo, Ida Marabese, Livio Luongo, Serena Boccella, Giulia Bellini, Maria Elvira Giordano, Francesca Rossi, Mariantonietta Scafuro, Vito de Novellis and Sabatino Maione

    Citation: Molecular Pain 2013 9:44

    Content type: Research

    Published on:

  5. A fundamental characteristic of neural circuits is the capacity for plasticity in response to experience. Neural plasticity is associated with the development of chronic pain disorders. In this study, we inves...

    Authors: Jian Kong, Rosa B Spaeth, Hsiao-Ying Wey, Alexandra Cheetham, Amanda H Cook, Karin Jensen, Ying Tan, Hesheng Liu, Danhong Wang, Marco L Loggia, Vitaly Napadow, Jordan W Smoller, Ajay D Wasan and Randy L Gollub

    Citation: Molecular Pain 2013 9:43

    Content type: Research

    Published on:

  6. IL-6 is a typical injury-induced mediator. Together with its receptors, IL-6 contributes to both induction and maintenance of neuropathic pain deriving from changes in activity of primary sensory neurons in do...

    Authors: Václav Brázda, Ilona Klusáková, Ivana Hradilová Svíženská and Petr Dubový

    Citation: Molecular Pain 2013 9:42

    Content type: Research

    Published on:

  7. CRPS is a painful, debilitating, and often-chronic condition characterized by various sensory, motor, and vascular disturbances. Despite many years of study, current treatments are limited by our understanding...

    Authors: Joseph J Gallagher, Maral Tajerian, Tianzhi Guo, Xiaoyou Shi, Wenwu Li, Ming Zheng, Gary Peltz, Wade S Kingery and J David Clark

    Citation: Molecular Pain 2013 9:40

    Content type: Research

    Published on:

  8. NaV1.7 is preferentially expressed, at relatively high levels, in peripheral neurons, and is often referred to as a “peripheral” sodium channel, and NaV1.7-specific blockers are under study as potential pain ther...

    Authors: Joel A Black, Janneke GJ Hoeijmakers, Catharina G Faber, Ingemar SJ Merkies and Stephen G Waxman

    Citation: Molecular Pain 2013 9:39

    Content type: Research

    Published on:

  9. It has been demonstrated that angiotensin II (Ang II) participates in either the inhibition or the facilitation of nociceptive transmission depending on the brain area. Neuronal Ang II is locally synthesized n...

    Authors: Wataru Nemoto, Osamu Nakagawasai, Fukie Yaoita, Syu-Ichi Kanno, Shin Yomogida, Masaaki Ishikawa, Takeshi Tadano and Koichi Tan-No

    Citation: Molecular Pain 2013 9:38

    Content type: Research

    Published on:

  10. We have previously shown a sprouting of sympathetic fibers into the upper dermis of the skin following subcutaneous injection of complete Freund’s adjuvant (CFA) into the hindpaw. This sprouting correlated wit...

    Authors: Maria Osikowicz, Geraldine Longo, Simon Allard, A Claudio Cuello and Alfredo Ribeiro-da-Silva

    Citation: Molecular Pain 2013 9:37

    Content type: Research

    Published on:

    The Erratum to this article has been published in Molecular Pain 2013 9:55

  11. There is considerable interest in inducing RNA interference (RNAi) in neurons to study gene function and identify new targets for disease intervention. Although short interfering RNAs (siRNAs) have been used t...

    Authors: Akira Machida, Hiroya Kuwahara, Azat Mayra, Takayuki Kubodera, Takashi Hirai, Fumiko Sunaga, Mio Tajiri, Yukihiko Hirai, Takashi Shimada, Hidehiro Mizusawa and Takanori Yokota

    Citation: Molecular Pain 2013 9:36

    Content type: Research

    Published on:

  12. Clinical studies indicate that patients with post-traumatic stress disorder (PTSD) frequently share comorbidity with numerous chronic pain conditions. However, the sustained effects of PTSD-like stress over ti...

    Authors: Yu-Qin He, Qiang Chen, Lei Ji, Zheng-Guo Wang, Zhi-Hong Bai, Robert L Stephens Jr and Min Yang

    Citation: Molecular Pain 2013 9:35

    Content type: Research

    Published on:

  13. Bilateral sagittal split ramus osteotomy (BSSRO) is a common orthognatic surgical procedure. Sensory disturbances in the inferior alveolar nerve, including hypoesthesia and dysesthesia, are frequently observed...

    Authors: Daisuke Kobayashi, Daisuke Nishizawa, Yoshito Takasaki, Shinya Kasai, Takashi Kakizawa, Kazutaka Ikeda and Ken-ichi Fukuda

    Citation: Molecular Pain 2013 9:34

    Content type: Research

    Published on:

  14. Repetitive transcranial magnetic stimulation (rTMS) has shown promise in the alleviation of acute and chronic pain by altering the activity of cortical areas involved in pain sensation. However, current single...

    Authors: Alexander Tzabazis, Carina Mari Aparici, Michael C Rowbotham, M Bret Schneider, Amit Etkin and David C Yeomans

    Citation: Molecular Pain 2013 9:33

    Content type: Research

    Published on:

    The Erratum to this article has been published in Molecular Pain 2014 10:16

  15. Cannabinoid receptors and T-type calcium channels are potential targets for treating pain. Here we report on the design, synthesis and analgesic properties of a new mixed cannabinoid/T-type channel ligand, NMP...

    Authors: Vinicius M Gadotti, Haitao You, Ravil R Petrov, N Daniel Berger, Philippe Diaz and Gerald W Zamponi

    Citation: Molecular Pain 2013 9:32

    Content type: Research

    Published on:

  16. This review aims to create an overview of the currently available results of site-directed mutagenesis studies on transient receptor potential vanilloid type 1 (TRPV1) receptor. Systematization of the vast num...

    Authors: Zoltán Winter, Andrea Buhala, Ferenc Ötvös, Katalin Jósvay, Csaba Vizler, György Dombi, Gerda Szakonyi and Zoltán Oláh

    Citation: Molecular Pain 2013 9:30

    Content type: Review

    Published on:

  17. Both spinal and trigeminal somatosensory systems use the TRPM8 channel as a principal transducer for detecting cold stimuli. It is currently unclear whether this cold transducer may play a role in trigeminal n...

    Authors: Xiaozhuo Zuo, Jennifer X Ling, Guang-Yin Xu and Jianguo G Gu

    Citation: Molecular Pain 2013 9:28

    Content type: Research

    Published on:

  18. The quantification of pain intensity in vivo is essential for identifying the mechanisms of various types of pain or for evaluating the effects of different analgesics. A variety of behavioral tests for pain meas...

    Authors: Hawon Cho, Yongwoo Jang, Byeongjun Lee, Hyeyoun Chun, Jooyoung Jung, Sung Min Kim, Sun Wook Hwang and Uhtaek Oh

    Citation: Molecular Pain 2013 9:25

    Content type: Research

    Published on:

  19. Odontoblasts are specialized cells that form dentin and they are believed to be sensors for tooth pain. Transforming growth factor-β1 (TGF-β1), a pro-inflammatory cytokine expressed early in odontoblasts, play...

    Authors: Elias Utreras, Michaela Prochazkova, Anita Terse, Jacklyn Gross, Jason Keller, Michael J Iadarola and Ashok B Kulkarni

    Citation: Molecular Pain 2013 9:24

    Content type: Research

    Published on:

  20. An inositol 1,4,5-trisphosphate binding protein, comprising 2 isoforms termed PRIP-1 and PRIP-2, was identified as a novel modulator for GABAA receptor trafficking. It has been reported that naive PRIP-1 knockout...

    Authors: Tomoya Kitayama, Katsuya Morita, Rizia Sultana, Nami Kikushige, Keisuke Mgita, Shinya Ueno, Masato Hirata and Takashi Kanematsu

    Citation: Molecular Pain 2013 9:23

    Content type: Short report

    Published on:

  21. Noxious stimulation and nerve injury induce an increase in intracellular Ca2+ concentration ([Ca2+]i) via various receptors or ionic channels. While an increase in [Ca2+]i excites neurons, [Ca2+]i overload elicit...

    Authors: Hidetaka Kuroda, Ubaidus Sobhan, Masaki Sato, Maki Tsumura, Tatsuya Ichinohe, Masakazu Tazaki and Yoshiyuki Shibukawa

    Citation: Molecular Pain 2013 9:22

    Content type: Research

    Published on:

  22. Peripheral nerve injury can have long-term consequences including pain-related manifestations, such as hypersensitivity to cutaneous stimuli, as well as affective and cognitive disturbances, suggesting the inv...

    Authors: Sebastian Alvarado, Maral Tajerian, Magali Millecamps, Mathew Suderman, Laura S Stone and Moshe Szyf

    Citation: Molecular Pain 2013 9:21

    Content type: Research

    Published on:

  23. Pain tolerance is subject to considerable inter-individual variation, which may be influenced by a number of genetic and non-genetic factors. The mu, delta and kappa opioid receptors play a role in pain percep...

    Authors: Hiroe Sato, Joanne Droney, Joy Ross, Anne Estrup Olesen, Camilla Staahl, Trine Andresen, Ruth Branford, Julia Riley, Lars Arendt-Nielsen and Asbjørn Mohr Drewes

    Citation: Molecular Pain 2013 9:20

    Content type: Research

    Published on:

  24. Preoperative pain, type of operation and anesthesia, severity of acute postoperative pain, and psychosocial factors have been identified as risk factors for chronic postsurgical pain (CPP). Recently, it has be...

    Authors: Yuri Kolesnikov, Boris Gabovits, Ariel Levin, Andres Veske, Li Qin, Feng Dai and Inna Belfer

    Citation: Molecular Pain 2013 9:19

    Content type: Research

    Published on:

  25. Electroacupuncture (EA) is effective in relieving pain in patients with postherpetic neuralgia (PHN). However, the mechanism underlying the therapeutic effect of EA in PHN is still unclear. Systemic injection ...

    Authors: Cai-hua Wu, Zheng-tao Lv, Yin Zhao, Yan Gao, Jia-qing Li, Fang Gao, Xian-fang Meng, Bo Tian, Jing Shi, Hui-lin Pan and Man Li

    Citation: Molecular Pain 2013 9:18

    Content type: Research

    Published on:

  26. Chronic low back pain is a major cause of disability and health care costs. Current treatments are inadequate for many patients. A number of preclinical models have been developed that attempt to mimic aspects...

    Authors: Judith A Strong, Wenrui Xie, Feguens J Bataille and Jun-Ming Zhang

    Citation: Molecular Pain 2013 9:17

    Content type: Review

    Published on:

  27. Proinflammatory cytokine interleukin-1β (IL-1β) released from spinal microglia plays an important role in the maintenance of acute and chronic pain states. However, the cellular basis of this action remains po...

    Authors: Tao Liu, Chang-Yu Jiang, Tsugumi Fujita, Shi-Wen Luo and Eiichi Kumamoto

    Citation: Molecular Pain 2013 9:16

    Content type: Research

    Published on:

  28. Visceral pain is common symptom involved in many gastrointestinal disorders such as inflammatory bowel disease. The underlying molecular mechanisms remain elusive. We investigated the molecular mechanisms and ...

    Authors: Aihua Qian, Dandan Song, Yong Li, Xinqiu Liu, Dong Tang, Weiyan Yao and Yaozong Yuan

    Citation: Molecular Pain 2013 9:15

    Content type: Research

    Published on:

  29. Peripheral nerve injury (PNI) results in a fundamental reorganization of the translational machinery in the injured peripheral nerve such that protein synthesis is increased in a manner linked to enhanced mTOR...

    Authors: Ohannes K Melemedjian, Hussein N Yassine, Adia Shy and Theodore J Price

    Citation: Molecular Pain 2013 9:14

    Content type: Research

    Published on:

  30. Previous studies have demonstrated that p38 MAPK signal transduction pathway plays an important role in the development and maintenance of inflammatory pain. Electroacupuncture (EA) can suppress the inflammato...

    Authors: Jian-Qiao Fang, Jun-Ying Du, Yi Liang and Jun-Fan Fang

    Citation: Molecular Pain 2013 9:13

    Content type: Research

    Published on:

  31. The editors of Molecular Pain would like to thank all the reviewers who have contributed to the journal in Volume 8 (2012).

    Authors: Jianguo Gu and Min Zhuo

    Citation: Molecular Pain 2013 9:10

    Content type: Reviewer acknowledgement

    Published on:

  32. Chronic pain is an important medical problem affecting hundreds of millions of people worldwide. Mechanisms underlying the maintenance of chronic pain states are poorly understood but the elucidation of such m...

    Authors: Ohannes K Melemedjian, Dipti V Tillu, Marina N Asiedu, Edward K Mandell, Jamie K Moy, Victoria M Blute, Caleb J Taylor, Sourav Ghosh and Theodore J Price

    Citation: Molecular Pain 2013 9:12

    Content type: Research

    Published on:

  33. Acute opioid tolerance (AOT) and opioid-induced hyperalgesia (OIH) are undesirable effects of opioids that have been reported in both animals and humans. However, the development of AOT and OIH in cases of pot...

    Authors: Hideaki Ishii, Andrey B Petrenko, Tatsuro Kohno and Hiroshi Baba

    Citation: Molecular Pain 2013 9:11

    Content type: Research

    Published on:

  34. Opioid receptors regulate a diverse array of physiological functions. Mu opioid receptor agonists are well-known analgesics for treating acute pain. In contrast, animal models suggest that chronic pain is more...

    Authors: Amynah Pradhan, Monique Smith, Brenna McGuire, Christopher Evans and Wendy Walwyn

    Citation: Molecular Pain 2013 9:8

    Content type: Research

    Published on:

  35. Cadmium (Cd) is an environmental pollutant and acute exposure to it causes symptoms related to pain and inflammation in the airway and gastrointestinal tract, but the underlying mechanisms are still unclear. T...

    Authors: Saeko Miura, Kenji Takahashi, Toshiaki Imagawa, Kunitoshi Uchida, Shigeru Saito, Makoto Tominaga and Toshio Ohta

    Citation: Molecular Pain 2013 9:7

    Content type: Research

    Published on:

  36. GTP cyclohydrolase 1 (GTP-CH1), the rate-limiting enzyme in the synthesis of tetrahydrobiopterin (BH4), encoded by the GCH1 gene, has been implicated in the development and maintenance of inflammatory pain in rat...

    Authors: Arafat Nasser, Ole J Bjerrum, Anne-Marie Heegaard, Anette T Møller, Majbritt Larsen, Louise S Dalbøge, Erik Dupont, Troels S Jensen and Lisbeth B Møller

    Citation: Molecular Pain 2013 9:5

    Content type: Research

    Published on:

  37. Hydrogen sulfide (H2S), an endogenous gaseotransmitter/modulator, is becoming appreciated that it may be involved in a wide variety of processes including inflammation and nociception. However, the role and mecha...

    Authors: Xingmei Feng, You-Lang Zhou, Xiaowen Meng, Fei-Hu Qi, Wei Chen, Xinghong Jiang and Guang-Yin Xu

    Citation: Molecular Pain 2013 9:4

    Content type: Research

    Published on:

  38. Resveratrol (3,5,4’ - trihydroxy-trans-stilbene), a widely distributed natural stilbenoid, was proposed to account for the unique effects of red wine on life span and health. It has been reported to possess va...

    Authors: Lina Yu, Shenglan Wang, Yoko Kogure, Satoshi Yamamoto, Koichi Noguchi and Yi Dai

    Citation: Molecular Pain 2013 9:3

    Content type: Research

    Published on:

  39. The TRPV1 ion channel is expressed in nociceptors, where pharmacological modulation of its function may offer a means of alleviating pain and neurogenic inflammation processes in the human body. The aim of thi...

    Authors: Erik T Jansson, Carolina L Trkulja, Aikeremu Ahemaiti, Maria Millingen, DM Gavin Jeffries, Kent Jardemark and Owe Orwar

    Citation: Molecular Pain 2013 9:1

    Content type: Research

    Published on:

  40. CREB has been reported to be activated by injury and is commonly used as marker for pain-related plasticity changes in somatosensory pathways, including spinal dorsal horn neurons and the anterior cingulate co...

    Authors: Giannina Descalzi, Hotaka Fukushima, Akinobu Suzuki, Satoshi Kida and Min Zhuo

    Citation: Molecular Pain 2012 8:90

    Content type: Short report

    Published on:

  41. Our previous studies have indicated that both lumbar spinal cord-infiltrating CD4+ T cells and microglial CD40 contribute to the maintenance of mechanical hypersensitivity in a murine model of neuropathic pain sp...

    Authors: Ling Cao, Holly Beaulac and Adriana Eurich

    Citation: Molecular Pain 2012 8:88

    Content type: Research

    Published on: