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  1. Irritable bowel syndrome (IBS) is characterized by chronic visceral hyperalgesia (CVH) that manifested with persistent or recurrent abdominal pain and altered bowel movement. However, the pathogenesis of the C...

    Authors: Lin Li, Ruihua Xie, Shufen Hu, Yongmeng Wang, Tianzhu Yu, Ying Xiao, Xinghong Jiang, Jianguo Gu, Chuang-Ying Hu and Guang-Yin Xu
    Citation: Molecular Pain 2012 8:89
    Content type: Research Published on:

  3. Essential oils are often used in alternative medicine as analgesic and anti-inflammatory remedies. However, the specific compounds that confer the effects of essential oils and the molecular mechanisms are lar...

    Authors: Masayuki Takaishi, Fumitaka Fujita, Kunitoshi Uchida, Satoshi Yamamoto, Maki Sawada (Shimizu), Chihiro Hatai (Uotsu), Mayumi Shimizu and Makoto Tominaga
    Citation: Molecular Pain 2012 8:86
    Content type: Research Published on:

  4. Distal limb fracture in man can induce a complex regional pain syndrome (CRPS) with pain, warmth, edema, and cutaneous inflammation. In the present study substance P (SP, Tac1−/−) and CGRP receptor (RAMP1−/−) def...

    Authors: Tian-Zhi Guo, Tzuping Wei, Xiaoyou Shi, Wen-Wu Li, Saiyun Hou, Liping Wang, Kazutake Tsujikawa, Kenner C Rice, Kejun Cheng, David J Clark and Wade S Kingery
    Citation: Molecular Pain 2012 8:85
    Content type: Research Published on:

  5. Neuropathic pain is detrimental to human health; however, its pathogenesis still remains largely unknown. Overexpression of pain-associated genes and increased nociceptive somato-sensitivity are well observed ...

    Authors: Xiao-Yan Zhu, Chang-Sheng Huang, Qian Li, Rui-min Chang, Zong-bing Song, Wang-yuan Zou and Qu-Lian Guo
    Citation: Molecular Pain 2012 8:84
    Content type: Research Published on:

  6. Proopiomelanocortin (POMC)-derived beta-endorphin1-31 from immune cells can inhibit inflammatory pain. Here we investigated cytokine signaling pathways regulating POMC gene expression and beta-endorphin productio...

    Authors: Melanie Busch-Dienstfertig, Dominika Labuz, Theresa Wolfram, Nicole N Vogel and Christoph Stein
    Citation: Molecular Pain 2012 8:83
    Content type: Research Published on:

  7. Sodium channel Nav1.7 has emerged as a target of considerable interest in pain research, since loss-of-function mutations in SCN9A, the gene that encodes Nav1.7, are associated with a syndrome of congenital insen...

    Authors: Joel A Black, Noémie Frézel, Sulayman D Dib-Hajj and Stephen G Waxman
    Citation: Molecular Pain 2012 8:82
    Content type: Research Published on:

  8. Peripheral nerve injuries often trigger a hypersensitivity to tactile stimulation. Behavioural studies demonstrated efficient and side effect-free analgesia mediated by opioid receptors on peripheral sensory n...

    Authors: Yvonne Schmidt, Dominika Labuz, Paul A Heppenstall and Halina Machelska
    Citation: Molecular Pain 2012 8:81
    Content type: Research Published on:

  9. Secretagogin (Scgn), a member of the EF-hand calcium-binding protein (CaBP) superfamily, has recently been found in subsets of developing and adult neurons. Here, we have analyzed the expression of Scgn in dor...

    Authors: Tie-Jun Sten Shi, Qiong Xiang, Ming-Dong Zhang, Giuseppe Tortoriello, Henrik Hammarberg, Jan Mulder, Kaj Fried, Ludwig Wagner, Anna Josephson, Mathias Uhlén, Tibor Harkany and Tomas Hökfelt
    Citation: Molecular Pain 2012 8:80
    Content type: Research Published on:

  11. Our previous studies have shown that complete Freund’s adjuvant (CFA)-induced masseter inflammation and microinjection of the pro-inflammatory cytokine interleukin-1β (IL-1β) into the subnucleus interpolaris/s...

    Authors: Bryan Chai, Wei Guo, Feng Wei, Ronald Dubner and Ke Ren
    Citation: Molecular Pain 2012 8:78
    Content type: Research Published on:

  12. Pharmacological activation of type-2 metabotropic glutamate receptors (mGlu2 receptors) causes analgesia in experimental models of inflammatory and neuropathic pain. Presynaptic mGlu2 receptors are activated b...

    Authors: Matteo Bernabucci, Serena Notartomaso, Cristina Zappulla, Francesco Fazio, Milena Cannella, Marta Motolese, Giuseppe Battaglia, Valeria Bruno, Roberto Gradini and Ferdinando Nicoletti
    Citation: Molecular Pain 2012 8:77
    Content type: Research Published on:

  14. The Transient Receptor Potential (TRP) ion channel TRPA1 is a key player in pain pathways. Irritant chemicals activate ion channel TRPA1 via covalent modification of N-terminal cysteines. We and others have sh...

    Authors: Yingqi Weng, Patricia A Batista-Schepman, Marie E Barabas, Eli Q Harris, Thomas B Dinsmore, Elena A Kossyreva, Audra M Foshage, Michelle H Wang, Matthew J Schwab, Victoria M Wang, Cheryl L Stucky and Gina M Story
    Citation: Molecular Pain 2012 8:75
    Content type: Research Published on:

  15. Although neuroimaging techniques have provided insights into the function of brain regions involved in Trigeminal Neuropathic Pain (TNP) in humans, there is little understanding of the molecular mechanisms aff...

    Authors: Marcos Fabio DosSantos, Ilkka Kristian Martikainen, Thiago Dias Nascimento, Tiffany M Love, Misty Dawn Deboer, Eric C Maslowski, André Antonio Monteiro, Maurice Borges Vincent, Jon-Kar Zubieta and Alexandre F DaSilva
    Citation: Molecular Pain 2012 8:74
    Content type: Short report Published on:

  16. Oxidized linoleic acid metabolites (OLAMs) are a class of endogenous agonists to the transient receptor potential V1 (TRPV1) receptor. Although TRPV1 mediates inflammatory heat hyperalgesia, it is not known if...

    Authors: Shivani Ruparel, Dustin Green, Paul Chen and Kenneth M Hargreaves
    Citation: Molecular Pain 2012 8:73
    Content type: Research Published on:

  17. Mutations in SCN9A, encoding the alpha subunit of the voltage-gated sodium channel (Nav1.7), have caused severe pain disorders and congenital insensitivity to pain. The aim of this study was to validate the previ...

    Authors: Kate L Holliday, Wendy Thomson, Tuhina Neogi, David T Felson, Ke Wang, Frederick C Wu, Ilpo T Huhtaniemi, Gyorgy Bartfai, Felipe Casanueva, Gianni Forti, Krzysztof Kula, Margus Punab, Dirk Vanderschueren, Gary J Macfarlane, Michael A Horan, William Ollier…
    Citation: Molecular Pain 2012 8:72
    Content type: Short report Published on:

  18. Chemotherapeutic agents produce dose-limiting peripheral neuropathy through mechanisms that remain poorly understood. We previously showed that AM1710, a cannabilactone CB2 agonist, produces antinociception witho...

    Authors: Liting Deng, Josée Guindon, V Kiran Vemuri, Ganesh A Thakur, Fletcher A White, Alexandros Makriyannis and Andrea G Hohmann
    Citation: Molecular Pain 2012 8:71
    Content type: Research Published on:

  19. The prevalence of long-term opiate use in treating chronic non-cancer pain is increasing, and prescription opioid abuse and dependence are a major public health concern. To explore alternatives to opioid-based...

    Authors: Evan E Lebovitz, Jason M Keller, Hal Kominsky, Krisztian Kaszas, Dragan Maric and Michael J Iadarola
    Citation: Molecular Pain 2012 8:70
    Content type: Research Published on:

  20. Gain-of-function mutations of the nociceptive voltage-gated sodium channel Nav1.7 lead to inherited pain syndromes, such as paroxysmal extreme pain disorder (PEPD). One characteristic of these mutations is slo...

    Authors: Alexandra B Klinger, Mirjam Eberhardt, Andrea S Link, Barbara Namer, Lisa K Kutsche, E Theresa Schuy, Ruth Sittl, Tali Hoffmann, Christian Alzheimer, Tobias Huth, Richard W Carr and Angelika Lampert
    Citation: Molecular Pain 2012 8:69
    Content type: Research Published on:

  21. Provoked vestibulodynia (PVD) is a pain disorder localized in the vestibular mucosa. It is the most common cause of dyspareunia among young women and it is associated with general pain hypersensitivity and oth...

    Authors: Ulrika Heddini, Nina Bohm-Starke, Alfhild Grönbladh, Fred Nyberg, Kent W Nilsson and Ulrika Johannesson
    Citation: Molecular Pain 2012 8:68
    Content type: Research Published on:

  22. Metabotropic glutamate receptors (mGluRs) have been identified as significant analgesic targets. Systemic treatments with inhibitors of the enzymes that inactivate the peptide transmitter N-acetylaspartylgluta...

    Authors: Toshihiko Yamada, Daiying Zuo, Tatsuo Yamamoto, Rafal T Olszewski, Tomasz Bzdega, John R Moffett and Joseph H Neale
    Citation: Molecular Pain 2012 8:67
    Content type: Research Published on:

  23. Migraine and other headache disorders affect a large percentage of the population and cause debilitating pain. Activation and sensitization of the trigeminal primary afferent neurons innervating the dura and c...

    Authors: Dongyue Huang, Shuyang Li, Ajay Dhaka, Gina M Story and Yu-Qing Cao
    Citation: Molecular Pain 2012 8:66
    Content type: Research Published on:

  24. Transforming growth factor beta (TGFβ) is upregulated in chronic inflammation, where it plays a key role in wound healing and promoting fibrosis. However, little is known about the peripheral effects of TGFβ o...

    Authors: Yaohui Zhu, Tugba Colak, Mohan Shenoy, Liansheng Liu, Kshama Mehta, Reetesh Pai, Bende Zou, Xinmin Simon Xie and Pankaj J Pasricha
    Citation: Molecular Pain 2012 8:65
    Content type: Research Published on:

  25. Pain-related (nociceptive) information is carried from the periphery to the dorsal horn of the spinal cord mostly by two populations of small diameter primary afferents, the peptidergic and the non-peptidergic...

    Authors: Abeer W Saeed and Alfredo Ribeiro-da-Silva
    Citation: Molecular Pain 2012 8:64
    Content type: Research Published on:

  26. In spite of its high clinical relevance, the relationship between disc degeneration and low back pain is still not well understood. Recent studies have shown that genome-wide gene expression studies utilizing ...

    Authors: Helen E Gruber, Gretchen L Hoelscher, Jane A Ingram and Edward N Hanley Jr
    Citation: Molecular Pain 2012 8:63
    Content type: Research Published on:

  27. Sickle cell disease (SCD) is associated with both acute vaso-occlusive painful events as well as chronic pain syndromes, including heightened sensitivity to touch. We have previously shown that mice with sever...

    Authors: Sheldon R Garrison, Audra A Kramer, Nashaat Z Gerges, Cheryl A Hillery and Cheryl L Stucky
    Citation: Molecular Pain 2012 8:62
    Content type: Short report Published on:

  28. The epidermis is innervated by fine nerve endings that are important in mediating nociceptive stimuli. However, their precise role in neuropathic pain is still controversial. Here, we have studied the role of ...

    Authors: Liron S Duraku, Mehdi Hossaini, Sieske Hoendervangers, Lukas L Falke, Shoista Kambiz, Vivek C Mudera, Joan C Holstege, Erik T Walbeehm and Tom J H Ruigrok
    Citation: Molecular Pain 2012 8:61
    Content type: Research Published on:

  29. Salvinorin A (SA), the main active component of Salvia Divinorum, is a non-nitrogenous kappa opioid receptor (KOR) agonist. It has been shown to reduce acute pain and to exert potent antinflammatory effects. This...

    Authors: Francesca Guida, Livio Luongo, Gabriella Aviello, Enza Palazzo, Maria De Chiaro, Luisa Gatta, Serena Boccella, Ida Marabese, Jordan K Zjawiony, Raffaele Capasso, Angelo A Izzo, Vito de Novellis and Sabatino Maione
    Citation: Molecular Pain 2012 8:60
    Content type: Research Published on:

  30. Postherpetic neuralgia is spontaneous pain and allodynia that persist long after the disappearance of the cutaneous lesions caused by herpes zoster. Inoculation of mice with herpes simplex virus-1 causes herpe...

    Authors: Sawako Unezaki, Atsushi Sasaki, Tamaki Mabuchi, Shinji Matsumura, Tayo Katano, Takanobu Nakazawa, Naoko Nishio, Tsugunobu Andoh, Tadashi Yamamoto, Terumasa Nakatsuka, Yasushi Kuraishi and Seiji Ito
    Citation: Molecular Pain 2012 8:59
    Content type: Research Published on:

  31. 5-hydroxytryptamine (5-HT) is one of the major neurotransmitters widely distributed in the CNS. Several 5-HT receptor subtypes have been identified in the spinal dorsal horn which act on both pre- and postsyna...

    Authors: Du-Jie Xie, Daisuke Uta, Peng-Yu Feng, Masahito Wakita, Min-Chul Shin, Hidemasa Furue and Megumu Yoshimura
    Citation: Molecular Pain 2012 8:58
    Content type: Research Published on:

  32. The neural mobilization technique is a noninvasive method that has proved clinically effective in reducing pain sensitivity and consequently in improving quality of life after neuropathic pain. The present stu...

    Authors: Fabio M Santos, Joyce T Silva, Aline C Giardini, Priscila A Rocha, Arnold PP Achermann, Adilson S Alves, Luiz RG Britto and Marucia Chacur
    Citation: Molecular Pain 2012 8:57
    Content type: Research Published on:

  33. Central sensitization in the spinal cord requires glutamate receptor activation and intracellular Ca2+ mobilization. We used Fura-2 AM bulk loading of mouse slices together with wide-field Ca2+ imaging to measure...

    Authors: Suzanne Doolen, Camille B Blake, Bret N Smith and Bradley K Taylor
    Citation: Molecular Pain 2012 8:56
    Content type: Research Published on:

  34. Oxaliplatin, a platinum-based chemotherapeutic agent, causes an unusual acute peripheral neuropathy. Oxaliplatin-induced acute peripheral neuropathy appears in almost all patients rapidly after infusion, and i...

    Authors: Meng Zhao, Kouichi Isami, Saki Nakamura, Hisashi Shirakawa, Takayuki Nakagawa and Shuji Kaneko
    Citation: Molecular Pain 2012 8:55
    Content type: Research Published on:

  35. The ubiquity of protein-protein interactions in biological signaling offers ample opportunities for therapeutic intervention. We previously identified a peptide, designated CBD3, that suppressed inflammatory a...

    Authors: Andrew D Piekarz, Michael R Due, May Khanna, Bo Wang, Matthew S Ripsch, Ruizhong Wang, Samy O Meroueh, Michael R Vasko, Fletcher A White and Rajesh Khanna
    Citation: Molecular Pain 2012 8:54
    Content type: Research Published on:

  36. The neurons in neocortex layer I (LI) provide inhibition to the cortical networks. Despite increasing use of mice for the study of brain functions, few studies were reported about mouse LI neurons. In the pres...

    Authors: Xiang-Yao Li, Tao Chen, Giannina Descalzi, Kohei Koga, Shuang Qiu and Min Zhuo
    Citation: Molecular Pain 2012 8:53
    Content type: Research Published on:

  37. Itch is one of the major somatosensory modalities. Some recent findings have proposed that gastrin releasing peptide (Grp) is expressed in a subset of dorsal root ganglion (DRG) neurons and functions as a sele...

    Authors: Michael S Fleming, Daniel Ramos, Seung Baek Han, Jianyuan Zhao, Young-Jin Son and Wenqin Luo
    Citation: Molecular Pain 2012 8:52
    Content type: Research Published on:

  38. Neurons in the capsular part of the central nucleus of the amygdala (CeC), a region also called "nociceptive amygdala," receive nociceptive information from the dorsal horn via afferent pathways relayed from t...

    Authors: Ayano Nakao, Yukari Takahashi, Masashi Nagase, Ryo Ikeda and Fusao Kato
    Citation: Molecular Pain 2012 8:51
    Content type: Research Published on:

  39. It was recently reported that the mono-iodoacetate (MIA) experimental model of osteoarthritis (OA) courses with changes of neurons innervating the affected joints that are commonly interpreted as a neuronal re...

    Authors: Joana Ferreira-Gomes, Sara Adães, Raquel Meireles Sousa, Marcelo Mendonça and José Manuel Castro-Lopes
    Citation: Molecular Pain 2012 8:50
    Content type: Research Published on:

  40. Minocycline has proven anti-nociceptive effects, but the mechanism by which minocycline delays the development of allodynia and hyperalgesia after peripheral nerve injury remains unclear. Inflammatory cells, i...

    Authors: Pejman Ghanouni, Deepak Behera, Jin Xie, Xiaoyuan Chen, Michael Moseley and Sandip Biswal
    Citation: Molecular Pain 2012 8:49
    Content type: Research Published on:

  41. Cystitis causes considerable neuronal plasticity in the primary afferent pathways. The molecular mechanism and signal transduction underlying cross talk between the inflamed urinary bladder and sensory sensiti...

    Authors: Sharon J Yu, Chun-mei Xia, Jarren C Kay and Li-Ya Qiao
    Citation: Molecular Pain 2012 8:48
    Content type: Research Published on:

  42. Central sensitization-associated synaptic plasticity in the spinal cord dorsal horn (SCDH) critically contributes to the development of chronic pain, but understanding of the underlying molecular pathways is s...

    Authors: Yuqiang Shi, Subo Yuan, Bei Li, Jigong Wang, Susan M Carlton, Kyungsoon Chung, Jin Mo Chung and Shao-Jun Tang
    Citation: Molecular Pain 2012 8:47
    Content type: Research Published on:

  43. The plasma membrane Ca2+-ATPase (PMCA) is the principal means by which sensory neurons expel Ca2+ and thereby regulate the concentration of cytoplasmic Ca2+ and the processes controlled by this critical second me...

    Authors: Geza Gemes, Katherine D Oyster, Bin Pan, Hsiang-En Wu, Madhavi Latha Yadav Bangaru, Qingbo Tang and Quinn H Hogan
    Citation: Molecular Pain 2012 8:46
    Content type: Research Published on:

  44. Antidepressants, which are widely used for treatment of chronic pain, are thought to have antinociceptive effects by blockade of serotonin and noradrenaline reuptake. However, these drugs also interact with va...

    Authors: Tatsuro Kohno, Masafumi Kimura, Mika Sasaki, Hideaki Obata, Fumimasa Amaya and Shigeru Saito
    Citation: Molecular Pain 2012 8:45
    Content type: Research Published on:

  45. Changes in the blood-central nervous system barriers occur under pathological conditions including inflammation and contribute to central manifestations of various diseases. After short-lasting peripheral and ...

    Authors: Dimitris N Xanthos, Isabella Püngel, Gabriele Wunderbaldinger and Jürgen Sandkühler
    Citation: Molecular Pain 2012 8:44
    Content type: Research Published on:

  46. The development of pain after peripheral nerve and tissue injury involves not only neuronal pathways but also immune cells and glia. Central sensitization is thought to be a mechanism for such persistent pain,...

    Authors: Hiroshi Ikeda, Takaki Kiritoshi and Kazuyuki Murase
    Citation: Molecular Pain 2012 8:43
    Content type: Research Published on:

  47. The polypeptide hormone calcitonin is clinically well known for its ability to relieve neuropathic pain such as spinal canal stenosis, diabetic neuropathy and complex regional pain syndrome. Mechanisms for its...

    Authors: Akitoshi Ito, Mineko Takeda, Takeshi Yoshimura, Takayuki Komatsu, Takeshi Ohno, Hiroshi Kuriyama, Akio Matsuda and Megumu Yoshimura
    Citation: Molecular Pain 2012 8:42
    Content type: Research Published on:

  49. Ethyl pyruvate (EP) possesses anti-inflammatory activity. However, the potential anti-nociceptive value of EP for the treatment of the inflammatory nociception is largely unknown. We investigated whether EP co...

    Authors: Min Jung Lee, Minhee Jang, Hyuk-Sang Jung, Sung-Hoon Kim and Ik-Hyun Cho
    Citation: Molecular Pain 2012 8:40
    Content type: Research Published on:

  50. Current tools for analgesia are often only partially successful, thus investigations of new targets for pain therapy stimulate great interest. Consequent to peripheral nerve injury, c-Jun N-terminal kinase (JN...

    Authors: Giusi Manassero, Ivan E Repetto, Stefano Cobianchi, Valeria Valsecchi, Christophe Bonny, Ferdinando Rossi and Alessandro Vercelli
    Citation: Molecular Pain 2012 8:39
    Content type: Research Published on:

Molecular Pain

ISSN: 1744-8069

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