Figure 4From: Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia Behavioral nociceptive responses to noxious heat, mechanical pressure and formalin injection were not altered in αCaMKII-F89G transgenic mice. A-B. Behavioral nociceptive responses to noxious heating in the tail-flick test at two different heating intensities (A) and the hot-plate test at three different temperatures (50, 52, 55°C) (B). No significant differences were found between wild-type and αCaMKII-F89G transgenic mice in any test. C-D. No significant differences were found in hind paw withdrawal responses to noxious heating or mechanical pressure. E. Behavioral nociceptive responses to hindpaw formalin injection, plotted in 5-min intervals, in wild type mice as compared to αCaMKII-F89G transgenic mice. No significant difference was found between wild-type and transgenic mice.Back to article page