Figure 6From: Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia Reduction in allodynia and hyperalgesia can be reversed by inhibiting the overexpression of CaMKII activity in αCaMKII-F89G transgenic mice. A. One-week pretreatment with the inhibitor 1NM-PP1 reversed the reduction of behavioral allodynia in αCaMKII-F89G transgenic mice. No significant difference was found between wild-type mice and αCaMKII-F89G transgenic mice receiving 1NM-PP1 pretreatment. B. One-week pretreatment with 1NM-PP1 reversed the reduction of behavioral hyperalgesia in αCaMKII-F89G transgenic mice. No significant difference was found between wild-type mice and αCaMKII-F89G transgenic mice receiving 1NM-PP1 pretreatment.Back to article page