Figure 3
From: Sensitization and translocation of TRPV1 by insulin and IGF-I
Singnaling cascades utilized by Insulin and IGF-I. a, Summary graph showing fold increase of current in the presence of IGF-I and the inhibitors: genistein (50 μM, n = 6, P < .05), lavendustin A (100 μM, n = 7, P < .05), wortmannin (100 nM, n = 5, P < .05) and BIM (200 nM, n = 5, P < .05). b, A PKC phosphorylation site TRPV1 mutant (S502A/S800A) (n = 6, P < .01, upper trace) and cytochalasin D (1 μM, n = 4, P < .01, lower trace) completely blocked insulin potentiation.