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  1. Content type: Research

    Diabetic neuropathy in visceral organs such as the gastrointestinal (GI) tract is still poorly understood, despite that GI symptoms are among the most common diabetic complications. The present study was desig...

    Authors: Li Dong, Xizi Liang, Biying Sun, Xiaowei Ding, Hongxiu Han, Guohua Zhang and Weifang Rong

    Citation: Molecular Pain 2015 11:74

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  2. Content type: Research

    Chronic stress has been reported to increase basal pain sensitivity and/or exacerbate existing persistent pain. However, most surgical patients have normal physiological and psychological health status such as...

    Authors: Jing Cao, Po-Kai Wang, Vinod Tiwari, Lingli Liang, Brianna Marie Lutz, Kun-Ruey Shieh, Wei-Dong Zang, Andrew G. Kaufman, Alex Bekker, Xiao-Qun Gao and Yuan-Xiang Tao

    Citation: Molecular Pain 2015 11:73

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  3. Content type: Research

    Trigeminal neuralgia is accompanied by severe mechanical, thermal and chemical hypersensitivity of the orofacial area innervated by neurons of trigeminal ganglion (TG). We examined the role of the voltage-gat...

    Authors: Ana Paula Luiz, Olga Kopach, Sonia Santana-Varela and John N. Wood

    Citation: Molecular Pain 2015 11:72

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  4. Content type: Research

    ATP-gated P2X3 receptors are important transducers of nociceptive stimuli and are almost exclusively expressed by sensory ganglion neurons. In mouse trigeminal ganglion (TG), P2X3 receptor function is unexpect...

    Authors: Anna Marchenkova, Sandra Vilotti, Elsa Fabbretti and Andrea Nistri

    Citation: Molecular Pain 2015 11:71

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  5. Content type: Research

    Altered kallikrein-related peptidase activity and bradykinin are associated with skin disorders in humans and mice under chronic inflammation conditions. The bradykinin B1 receptor (B1R), also known as one of ...

    Authors: Yuying Liu, Jianhua Liu, Mengran Li, Sailin Dai, Jiexian Liang and Wenjin Ji

    Citation: Molecular Pain 2015 11:70

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  6. Content type: Research

    Peripheral cold neuropathic pain is a serious side effect of oxaliplatin treatment. However, the mechanism of oxaliplatin-induced cold hyperalgesia is unknown. In the present study, we investigated the effects...

    Authors: Ken Yamamoto, Noriko Chiba, Terumasa Chiba, Toshie Kambe, Kenji Abe, Kazuyoshi Kawakami, Iku Utsunomiya and Kyoji Taguchi

    Citation: Molecular Pain 2015 11:69

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  7. Content type: Research

    Recent advances in brain imaging have contributed to our understanding of the neural activity associated with acupuncture treatment. In this study, we investigated functional connectivity across longitudinal a...

    Authors: Xiaoyan Chen, Rosa B. Spaeth, Sonya G. Freeman, Donna Moxley Scarborough, Javeria A. Hashmi, Hsiao-Ying Wey, Natalia Egorova, Mark Vangel, Jianren Mao, Ajay D. Wasan, Robert R. Edwards, Randy L. Gollub and Jian Kong

    Citation: Molecular Pain 2015 11:67

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  8. Content type: Research

    Molecular mediators influencing the transition from acute to persistent musculoskeletal pain following common stress exposures such as motor vehicle collision (MVC) remain poorly understood. In this explorator...

    Authors: Sarah D. Linnstaedt, Margaret G. Walker, Joel S. Parker, Eunice Yeh, Robert L. Sons, Erin Zimny, Christopher Lewandowski, Phyllis L. Hendry, Kathia Damiron, Claire Pearson, Marc-Anthony Velilla, Brian J. O’Neil, Jeffrey Jones, Robert Swor, Robert Domeier, Scott Hammond…

    Citation: Molecular Pain 2015 11:66

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  9. Content type: Research

    We evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous me...

    Authors: Luiz F. Ferrari, Oliver Bogen, Paul Green and Jon D. Levine

    Citation: Molecular Pain 2015 11:65

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  10. Content type: Research

    Presynaptic GABAA receptors (GABAARs) located on central terminals of low threshold afferent fibers are thought to be involved in the processing of touch and possibly in the generation of tactile allodynia in chr...

    Authors: Chiara Betelli, Amy B. MacDermott and Rita Bardoni

    Citation: Molecular Pain 2015 11:64

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  11. Content type: Research

    Increased electrical activity in peripheral sensory neurons including dorsal root ganglia (DRG) and trigeminal ganglia neurons is an important mechanism underlying pain. Voltage gated sodium channels (VGSC) co...

    Authors: Cindy Barbosa, Zhi-Yong Tan, Ruizhong Wang, Wenrui Xie, Judith A. Strong, Reesha R. Patel, Michael R. Vasko, Jun-Ming Zhang and Theodore R. Cummins

    Citation: Molecular Pain 2015 11:60

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  12. Content type: Research

    Cuff and spared nerve injury (SNI) in the sciatic territory are widely used to model neuropathic pain. Because nociceptive information is first detected in skin, it is important to understand how alterations i...

    Authors: Francisney P. Nascimento, Claire Magnussen, Noosha Yousefpour and Alfredo Ribeiro-da-Silva

    Citation: Molecular Pain 2015 11:59

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  13. Content type: Research

    Mitochondrial dysfunction is observed in various neuropathic pain phenotypes, such as chemotherapy induced neuropathy, diabetic neuropathy, HIV-associated neuropathy, and in Charcot-Marie-Tooth neuropathy. To ...

    Authors: Tony K. Y. Lim, Malena B. Rone, Seunghwan Lee, Jack P. Antel and Ji Zhang

    Citation: Molecular Pain 2015 11:58

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  14. Content type: Research

    Uterine contraction-induced pain (UCP) represents a common and severe form of visceral pain. Nerve fibers that innervate uterine tissue express the transient receptor potential vanilloid channel 1 (TRPV1), whi...

    Authors: Changming Wang, Zhongli Wang, Yan Yang, Chan Zhu, Guanyi Wu, Guang Yu, Tunyu Jian, Niuniu Yang, Hao Shi, Min Tang, Qian He, Lei Lan, Qin Liu, Yun Guan, Xinzhong Dong, Jinao Duan…

    Citation: Molecular Pain 2015 11:57

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  15. Content type: Research

    Plastic changes in the anterior cingulate cortex (ACC) are critical in the pathogenesis of pain hypersensitivity caused by injury to peripheral nerves. Cdh1, a co-activator subunit of anaphase-promoting comple...

    Authors: Wei Tan, Wen-Long Yao, Rong Hu, You-You Lv, Li Wan, Chuan-Han Zhang and Chang Zhu

    Citation: Molecular Pain 2015 11:56

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  16. Content type: Research

    Anoctamin 1 (ANO1 or TMEM16A) Ca2+-gated Cl channels of nociceptor neurons are emerging as important molecular components of peripheral pain transduction. At physiological intracellular Cl concentrations ([Cl]

    Authors: Farah Deba and Bret F. Bessac

    Citation: Molecular Pain 2015 11:55

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  17. Content type: Research

    Non-peptidergic nociceptive neurons are a sub-population of small diameter primary sensory neurons that comprise approximately 50 % of the C fiber population. Together with the peptidergic sub-population, they...

    Authors: Abeer W. Saeed, Sophie A. Pawlowski and Alfredo Ribeiro-da-Silva

    Citation: Molecular Pain 2015 11:54

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  18. Content type: Research

    LTB4 is classified as a leukotriene (LT), a group of lipid mediators that are derived from arachidonic acid. It is recognized that leukotrienes are involved in the pathogenesis of many diseases, including peri...

    Authors: Yasukuni Kiyoyuki, Wataru Taniguchi, Masamichi Okubo, Hiroki Yamanaka, Kimiko Kobayashi, Naoko Nishio, Terumasa Nakatsuka and Koichi Noguchi

    Citation: Molecular Pain 2015 11:53

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  19. Content type: Short report

    Fatty acid binding proteins (FABPs) serve as intracellular carriers that deliver endocannabinoids and N-acylethanolamines to their catabolic enzymes. Inhibition of FABPs reduces endocannabinoid transport and cata...

    Authors: Martin Kaczocha, Sherrye T. Glaser, Thomas Maher, Brendan Clavin, John Hamilton, Joseph O’Rourke, Mario Rebecchi, Michelino Puopolo, Yuji Owada and Panayotis K. Thanos

    Citation: Molecular Pain 2015 11:52

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  20. Content type: Research

    Arthritis pain is an important healthcare issue with significant emotional and affective consequences. Here we focus on potentially beneficial effects of activating small-conductance calcium-activated potassiu...

    Authors: Jeremy M. Thompson, Guangchen Ji and Volker Neugebauer

    Citation: Molecular Pain 2015 11:51

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  21. Content type: Research

    The periaqueductal gray region (PAG) is one of several brain areas identified to be vulnerable to structural and functional change following peripheral nerve injury. Sciatic nerve constriction injury (CCI) tri...

    Authors: David Mor, James W M Kang, Peter Wyllie, Vignaraja Thirunavukarasu, Hayden Houlton, Paul J Austin and Kevin A Keay

    Citation: Molecular Pain 2015 11:50

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  22. Content type: Short report

    The rostral anterior cingulate cortex (rACC) has been implicated in the negative affective response to injury, and importantly, it has been shown that activation of extracellular signal-regulated kinase (ERK) ...

    Authors: Keri K Tochiki, Maria Maiarù, James R C Miller, Stephen P Hunt and Sandrine M Géranton

    Citation: Molecular Pain 2015 11:49

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  23. Content type: Research

    Orofacial inflammatory pain is likely to accompany referred pain in uninflamed orofacial structures. The ectopic pain precludes precise diagnosis and makes treatment problematic, because the underlying mechani...

    Authors: Masaaki Kiyomoto, Masamichi Shinoda, Kuniya Honda, Yuka Nakaya, Ko Dezawa, Ayano Katagiri, Satoshi Kamakura, Tomio Inoue and Koichi Iwata

    Citation: Molecular Pain 2015 11:48

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  24. Content type: Research

    Although alterations in not only the pain sensitivity but also the analgesic effects of opioids have been reported under conditions of stress, the influence of unpredictable chronic mild stress (UCMS) on the a...

    Authors: Soichiro Ide, Hiroshi Satoyoshi, Masabumi Minami and Masamichi Satoh

    Citation: Molecular Pain 2015 11:47

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  25. Content type: Research

    Koumine is an alkaloid monomer found abundantly in Gelsemium plants. It has been shown to reverse thermal hyperalgesia and mechanical allodynia induced by sciatic nerve chronic constriction injury (CCI) in rats i...

    Authors: Hong-Qiang Qiu, Ying Xu, Gui-Lin Jin, Jian Yang, Ming Liu, Su-Ping Li and Chang-Xi Yu

    Citation: Molecular Pain 2015 11:46

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  26. Content type: Research

    Hyperexcitability of nociceptive afferent fibers is an underlying mechanism of neuropathic pain and ion channels involved in neuronal excitability are potentially therapeutic targets. KCNQ channels, a subfamil...

    Authors: Alaa A Abd-Elsayed, Ryo Ikeda, Zhanfeng Jia, Jennifer Ling, Xiaozhuo Zuo, Min Li and Jianguo G Gu

    Citation: Molecular Pain 2015 11:45

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  27. Content type: Research

    Increased nociceptive neuronal excitability underlies chronic pain conditions. Various ion channels, including sodium, calcium and potassium channels have pivotal roles in the control of neuronal excitability....

    Authors: Chuang Lyu, Jan Mulder, Swapnali Barde, Kristoffer Sahlholm, Hugo Zeberg, Johanna Nilsson, Peter Århem, Tomas Hökfelt, Kaj Fried and Tie-Jun Sten Shi

    Citation: Molecular Pain 2015 11:44

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  28. Content type: Research

    Neuropathic pain that caused by lesion or dysfunction of the nervous system is associated with gene expression changes in the sensory pathway. Long noncoding RNAs (lncRNAs) have been reported to be able to reg...

    Authors: Bao-Chun Jiang, Wen-Xing Sun, Li-Na He, De-Li Cao, Zhi-Jun Zhang and Yong-Jing Gao

    Citation: Molecular Pain 2015 11:43

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  29. Content type: Research

    Serotonergic raphespinal neurons and their fibers have been mapped in large mammals, but the non-serotonergic ones have not been studied, especially in the mouse. The present study aimed to investigate the ter...

    Authors: Huazheng Liang, Shaoshi Wang, Richard Francis, Renee Whan, Charles Watson and George Paxinos

    Citation: Molecular Pain 2015 11:42

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  30. Content type: Research

    Calcium-activated chloride channels (CaCCs) activation induces membrane depolarization by increasing chloride efflux in primary sensory neurons that can facilitate action potential generation. Previous studies...

    Authors: Jorge Baruch Pineda-Farias, Paulino Barragán-Iglesias, Emanuel Loeza-Alcocer, Jorge E Torres-López, Héctor Isaac Rocha-González, Francisca Pérez-Severiano, Rodolfo Delgado-Lezama and Vinicio Granados-Soto

    Citation: Molecular Pain 2015 11:41

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  31. Content type: Research

    Accumulating clinical and preclinical evidence indicates that chronic pain is often comorbid with persistent low mood and anxiety. However, the mechanisms underlying pain-induced anxiety, such as its causality...

    Authors: Lin Shang, Tian-Le Xu, Fei Li, Jiansheng Su and Wei-Guang Li

    Citation: Molecular Pain 2015 11:40

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    The Erratum to this article has been published in Molecular Pain 2015 11:62

  32. Content type: Research

    MicroRNAs (miRNAs) are involved in the neuroplastic changes which induce and maintain neuropathic pain. However, it is unknown whether nerve injury leads to altered miRNA expression and modulation of pain rele...

    Authors: Elena Neumann, Henning Hermanns, Franziska Barthel, Robert Werdehausen and Timo Brandenburger

    Citation: Molecular Pain 2015 11:39

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  33. Content type: Research

    The clinical efficacy of the Angiotensin II (AngII) receptor AT2R antagonist EMA401, a novel peripherally-restricted analgesic, was reported recently in post-herpetic neuralgia. While previous studies have shown ...

    Authors: Uma Anand, Yiangos Yiangou, Marco Sinisi, Michael Fox, Anthony MacQuillan, Tom Quick, Yuri E Korchev, Chas Bountra, Tom McCarthy and Praveen Anand

    Citation: Molecular Pain 2015 11:38

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  34. Content type: Research

    The descending antinociceptive system (DAS) is thought to play crucial roles in the antinociceptive effect of spinal cord stimulation (SCS), especially through its serotonergic pathway. The nucleus raphe magnu...

    Authors: Toshiharu Tazawa, Yoshinori Kamiya, Ayako Kobayashi, Kensuke Saeki, Masahito Takiguchi, Yusuke Nakahashi, Hironobu Shinbori, Kengo Funakoshi and Takahisa Goto

    Citation: Molecular Pain 2015 11:36

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  35. Content type: Research

    Neuropathic pain and sensory abnormalities are a debilitating secondary consequence of spinal cord injury (SCI). Maladaptive structural plasticity is gaining recognition for its role in contributing to the dev...

    Authors: Sonja K Bareiss, Elizabeth Dugan and Kori L Brewer

    Citation: Molecular Pain 2015 11:35

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  36. Content type: Research

    Morphine and fentanyl are opioid analgesics in wide clinical use that act through the μ-opioid receptor (MOR). However, one limitation of their long-term effectiveness is the development of tolerance. Receptor...

    Authors: David J. Marcus, Michael Zee, Alex Hughes, Matthew B. Yuill, Andrea G. Hohmann, Ken Mackie, Josée Guindon and Daniel J. Morgan

    Citation: Molecular Pain 2015 11:34

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  37. Content type: Research

    Neuropeptide Y (NPY) has been implicated in the modulation of pain. Under normal conditions, NPY is found in interneurons in the dorsal horn of the spinal cord and in sympathetic postganglionic neurons but is ...

    Authors: Claire Magnussen, Shih-Ping Hung and Alfredo Ribeiro-da-Silva

    Citation: Molecular Pain 2015 11:31

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  38. Content type: Research

    Previous studies have shown that increased excitability of capsaicin-sensitive DRG neurons and thermal hyperalgesia in rats with short-term (2–4 weeks) streptozotocin-induced diabetes is mediated by upregulati...

    Authors: Dmytro E Duzhyy, Viacheslav Y Viatchenko-Karpinski, Eugen V Khomula, Nana V Voitenko and Pavel V Belan

    Citation: Molecular Pain 2015 11:29

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  39. Content type: Research

    Pain is the most prominent non-motor symptom observed in patients with Parkinson’s disease (PD). However, the mechanisms underlying the generation of pain in PD have not been well studied. We used a 1-methyl-4...

    Authors: Jihye Park, Chae-Seok Lim, Hyunhyo Seo, Chung-Ah Park, Min Zhuo, Bong-Kiun Kaang and Kyungmin Lee

    Citation: Molecular Pain 2015 11:28

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  40. Content type: Review

    The complexity of chronic pain and the challenges of pharmacotherapy highlight the importance of development of new approaches to pain management. Gene therapy approaches may be complementary to pharmacotherap...

    Authors: Jean-Marc G Guedon, Shaogen Wu, Xuexing Zheng, Caroline C Churchill, Joseph C Glorioso, Ching-Hang Liu, Shue Liu, Lucy Vulchanova, Alex Bekker, Yuan-Xiang Tao, Paul R Kinchington, William F Goins, Carolyn A Fairbanks and Shuanglin Hao

    Citation: Molecular Pain 2015 11:27

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  41. Content type: Research

    The skin is a morphologically complex organ that serves multiple complementary functions, including an important role in thermoregulation, which is mediated by a rich vasculature that is innervated by sympathe...

    Authors: Frank L Rice, Phillip J Albrecht, James P Wymer, Joel A Black, Ingemar SJ Merkies, Catharina G Faber and Stephen G Waxman

    Citation: Molecular Pain 2015 11:26

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  42. Content type: Research

    Hydrogen sulfide (H2S) is oxidized to polysulfide. Recent reports show that this sulfur compound modulates various biological functions. We have reported that H2S is involved in inflammatory pain in mice. On the ...

    Authors: Yukari Hatakeyama, Kenji Takahashi, Makoto Tominaga, Hideo Kimura and Toshio Ohta

    Citation: Molecular Pain 2015 11:24

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