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  1. Content type: Research

    Diabetic neuropathy in visceral organs such as the gastrointestinal (GI) tract is still poorly understood, despite that GI symptoms are among the most common diabetic complications. The present study was desig...

    Authors: Li Dong, Xizi Liang, Biying Sun, Xiaowei Ding, Hongxiu Han, Guohua Zhang and Weifang Rong

    Citation: Molecular Pain 2015 11:74

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  2. Content type: Research

    Chronic stress has been reported to increase basal pain sensitivity and/or exacerbate existing persistent pain. However, most surgical patients have normal physiological and psychological health status such as...

    Authors: Jing Cao, Po-Kai Wang, Vinod Tiwari, Lingli Liang, Brianna Marie Lutz, Kun-Ruey Shieh, Wei-Dong Zang, Andrew G. Kaufman, Alex Bekker, Xiao-Qun Gao and Yuan-Xiang Tao

    Citation: Molecular Pain 2015 11:73

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  3. Content type: Research

    Trigeminal neuralgia is accompanied by severe mechanical, thermal and chemical hypersensitivity of the orofacial area innervated by neurons of trigeminal ganglion (TG). We examined the role of the voltage-gat...

    Authors: Ana Paula Luiz, Olga Kopach, Sonia Santana-Varela and John N. Wood

    Citation: Molecular Pain 2015 11:72

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  4. Content type: Research

    ATP-gated P2X3 receptors are important transducers of nociceptive stimuli and are almost exclusively expressed by sensory ganglion neurons. In mouse trigeminal ganglion (TG), P2X3 receptor function is unexpect...

    Authors: Anna Marchenkova, Sandra Vilotti, Elsa Fabbretti and Andrea Nistri

    Citation: Molecular Pain 2015 11:71

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  5. Content type: Research

    Altered kallikrein-related peptidase activity and bradykinin are associated with skin disorders in humans and mice under chronic inflammation conditions. The bradykinin B1 receptor (B1R), also known as one of ...

    Authors: Yuying Liu, Jianhua Liu, Mengran Li, Sailin Dai, Jiexian Liang and Wenjin Ji

    Citation: Molecular Pain 2015 11:70

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  6. Content type: Research

    Peripheral cold neuropathic pain is a serious side effect of oxaliplatin treatment. However, the mechanism of oxaliplatin-induced cold hyperalgesia is unknown. In the present study, we investigated the effects...

    Authors: Ken Yamamoto, Noriko Chiba, Terumasa Chiba, Toshie Kambe, Kenji Abe, Kazuyoshi Kawakami, Iku Utsunomiya and Kyoji Taguchi

    Citation: Molecular Pain 2015 11:69

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  7. Content type: Research

    Recent advances in brain imaging have contributed to our understanding of the neural activity associated with acupuncture treatment. In this study, we investigated functional connectivity across longitudinal a...

    Authors: Xiaoyan Chen, Rosa B. Spaeth, Sonya G. Freeman, Donna Moxley Scarborough, Javeria A. Hashmi, Hsiao-Ying Wey, Natalia Egorova, Mark Vangel, Jianren Mao, Ajay D. Wasan, Robert R. Edwards, Randy L. Gollub and Jian Kong

    Citation: Molecular Pain 2015 11:67

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  8. Content type: Research

    Molecular mediators influencing the transition from acute to persistent musculoskeletal pain following common stress exposures such as motor vehicle collision (MVC) remain poorly understood. In this explorator...

    Authors: Sarah D. Linnstaedt, Margaret G. Walker, Joel S. Parker, Eunice Yeh, Robert L. Sons, Erin Zimny, Christopher Lewandowski, Phyllis L. Hendry, Kathia Damiron, Claire Pearson, Marc-Anthony Velilla, Brian J. O’Neil, Jeffrey Jones, Robert Swor, Robert Domeier, Scott Hammond…

    Citation: Molecular Pain 2015 11:66

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  9. Content type: Research

    We evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous me...

    Authors: Luiz F. Ferrari, Oliver Bogen, Paul Green and Jon D. Levine

    Citation: Molecular Pain 2015 11:65

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  10. Content type: Research

    Presynaptic GABAA receptors (GABAARs) located on central terminals of low threshold afferent fibers are thought to be involved in the processing of touch and possibly in the generation of tactile allodynia in chr...

    Authors: Chiara Betelli, Amy B. MacDermott and Rita Bardoni

    Citation: Molecular Pain 2015 11:64

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  11. Content type: Research

    Increased electrical activity in peripheral sensory neurons including dorsal root ganglia (DRG) and trigeminal ganglia neurons is an important mechanism underlying pain. Voltage gated sodium channels (VGSC) co...

    Authors: Cindy Barbosa, Zhi-Yong Tan, Ruizhong Wang, Wenrui Xie, Judith A. Strong, Reesha R. Patel, Michael R. Vasko, Jun-Ming Zhang and Theodore R. Cummins

    Citation: Molecular Pain 2015 11:60

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  12. Content type: Research

    Cuff and spared nerve injury (SNI) in the sciatic territory are widely used to model neuropathic pain. Because nociceptive information is first detected in skin, it is important to understand how alterations i...

    Authors: Francisney P. Nascimento, Claire Magnussen, Noosha Yousefpour and Alfredo Ribeiro-da-Silva

    Citation: Molecular Pain 2015 11:59

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  13. Content type: Research

    Mitochondrial dysfunction is observed in various neuropathic pain phenotypes, such as chemotherapy induced neuropathy, diabetic neuropathy, HIV-associated neuropathy, and in Charcot-Marie-Tooth neuropathy. To ...

    Authors: Tony K. Y. Lim, Malena B. Rone, Seunghwan Lee, Jack P. Antel and Ji Zhang

    Citation: Molecular Pain 2015 11:58

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  14. Content type: Research

    Uterine contraction-induced pain (UCP) represents a common and severe form of visceral pain. Nerve fibers that innervate uterine tissue express the transient receptor potential vanilloid channel 1 (TRPV1), whi...

    Authors: Changming Wang, Zhongli Wang, Yan Yang, Chan Zhu, Guanyi Wu, Guang Yu, Tunyu Jian, Niuniu Yang, Hao Shi, Min Tang, Qian He, Lei Lan, Qin Liu, Yun Guan, Xinzhong Dong, Jinao Duan…

    Citation: Molecular Pain 2015 11:57

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  15. Content type: Research

    Plastic changes in the anterior cingulate cortex (ACC) are critical in the pathogenesis of pain hypersensitivity caused by injury to peripheral nerves. Cdh1, a co-activator subunit of anaphase-promoting comple...

    Authors: Wei Tan, Wen-Long Yao, Rong Hu, You-You Lv, Li Wan, Chuan-Han Zhang and Chang Zhu

    Citation: Molecular Pain 2015 11:56

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  16. Content type: Research

    Anoctamin 1 (ANO1 or TMEM16A) Ca2+-gated Cl channels of nociceptor neurons are emerging as important molecular components of peripheral pain transduction. At physiological intracellular Cl concentrations ([Cl]

    Authors: Farah Deba and Bret F. Bessac

    Citation: Molecular Pain 2015 11:55

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  17. Content type: Research

    LTB4 is classified as a leukotriene (LT), a group of lipid mediators that are derived from arachidonic acid. It is recognized that leukotrienes are involved in the pathogenesis of many diseases, including peri...

    Authors: Yasukuni Kiyoyuki, Wataru Taniguchi, Masamichi Okubo, Hiroki Yamanaka, Kimiko Kobayashi, Naoko Nishio, Terumasa Nakatsuka and Koichi Noguchi

    Citation: Molecular Pain 2015 11:53

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  18. Content type: Research

    Non-peptidergic nociceptive neurons are a sub-population of small diameter primary sensory neurons that comprise approximately 50 % of the C fiber population. Together with the peptidergic sub-population, they...

    Authors: Abeer W. Saeed, Sophie A. Pawlowski and Alfredo Ribeiro-da-Silva

    Citation: Molecular Pain 2015 11:54

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  19. Content type: Research

    Arthritis pain is an important healthcare issue with significant emotional and affective consequences. Here we focus on potentially beneficial effects of activating small-conductance calcium-activated potassiu...

    Authors: Jeremy M. Thompson, Guangchen Ji and Volker Neugebauer

    Citation: Molecular Pain 2015 11:51

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  20. Content type: Short report

    Fatty acid binding proteins (FABPs) serve as intracellular carriers that deliver endocannabinoids and N-acylethanolamines to their catabolic enzymes. Inhibition of FABPs reduces endocannabinoid transport and cata...

    Authors: Martin Kaczocha, Sherrye T. Glaser, Thomas Maher, Brendan Clavin, John Hamilton, Joseph O’Rourke, Mario Rebecchi, Michelino Puopolo, Yuji Owada and Panayotis K. Thanos

    Citation: Molecular Pain 2015 11:52

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  21. Content type: Research

    The periaqueductal gray region (PAG) is one of several brain areas identified to be vulnerable to structural and functional change following peripheral nerve injury. Sciatic nerve constriction injury (CCI) tri...

    Authors: David Mor, James W M Kang, Peter Wyllie, Vignaraja Thirunavukarasu, Hayden Houlton, Paul J Austin and Kevin A Keay

    Citation: Molecular Pain 2015 11:50

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