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  1. Research

    Short-term pre- and post-operative stress prolongs incision-induced pain hypersensitivity without changing basal pain perception

    Chronic stress has been reported to increase basal pain sensitivity and/or exacerbate existing persistent pain. However, most surgical patients have normal physiological and psychological health status such as...

    Jing Cao, Po-Kai Wang, Vinod Tiwari, Lingli Liang, Brianna Marie Lutz, Kun-Ruey Shieh, Wei-Dong Zang, Andrew G. Kaufman, Alex Bekker, Xiao-Qun Gao and Yuan-Xiang Tao

    Molecular Pain 2015 11:73

    Published on: 2 December 2015

  2. Research

    The effect of kinin B1 receptor on chronic itching sensitization

    Altered kallikrein-related peptidase activity and bradykinin are associated with skin disorders in humans and mice under chronic inflammation conditions. The bradykinin B1 receptor (B1R), also known as one of ...

    Yuying Liu, Jianhua Liu, Mengran Li, Sailin Dai, Jiexian Liang and Wenjin Ji

    Molecular Pain 2015 11:70

    Published on: 14 November 2015

  3. Research

    Transient receptor potential ankyrin 1 that is induced in dorsal root ganglion neurons contributes to acute cold hypersensitivity after oxaliplatin administration

    Peripheral cold neuropathic pain is a serious side effect of oxaliplatin treatment. However, the mechanism of oxaliplatin-induced cold hyperalgesia is unknown. In the present study, we investigated the effects...

    Ken Yamamoto, Noriko Chiba, Terumasa Chiba, Toshie Kambe, Kenji Abe, Kazuyoshi Kawakami, Iku Utsunomiya and Kyoji Taguchi

    Molecular Pain 2015 11:69

    Published on: 13 November 2015

  4. Research

    The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients

    Recent advances in brain imaging have contributed to our understanding of the neural activity associated with acupuncture treatment. In this study, we investigated functional connectivity across longitudinal a...

    Xiaoyan Chen, Rosa B. Spaeth, Sonya G. Freeman, Donna Moxley Scarborough, Javeria A. Hashmi, Hsiao-Ying Wey, Natalia Egorova, Mark Vangel, Jianren Mao, Ajay D. Wasan, Robert R. Edwards, Randy L. Gollub and Jian Kong

    Molecular Pain 2015 11:67

    Published on: 29 October 2015

  5. Research

    MicroRNA circulating in the early aftermath of motor vehicle collision predict persistent pain development and suggest a role for microRNA in sex-specific pain differences

    Molecular mediators influencing the transition from acute to persistent musculoskeletal pain following common stress exposures such as motor vehicle collision (MVC) remain poorly understood. In this explorator...

    Sarah D. Linnstaedt, Margaret G. Walker, Joel S. Parker, Eunice Yeh, Robert L. Sons, Erin Zimny, Christopher Lewandowski, Phyllis L. Hendry, Kathia Damiron, Claire Pearson, Marc-Anthony Velilla, Brian J. O’Neil, Jeffrey Jones, Robert Swor, Robert Domeier, Scott Hammond…

    Molecular Pain 2015 11:66

    Published on: 24 October 2015

  6. Research

    Contribution of Piezo2 to endothelium-dependent pain

    We evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous me...

    Luiz F. Ferrari, Oliver Bogen, Paul Green and Jon D. Levine

    Molecular Pain 2015 11:65

    Published on: 24 October 2015

  7. Research

    Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons

    Increased electrical activity in peripheral sensory neurons including dorsal root ganglia (DRG) and trigeminal ganglia neurons is an important mechanism underlying pain. Voltage gated sodium channels (VGSC) co...

    Cindy Barbosa, Zhi-Yong Tan, Ruizhong Wang, Wenrui Xie, Judith A. Strong, Reesha R. Patel, Michael R. Vasko, Jun-Ming Zhang and Theodore R. Cummins

    Molecular Pain 2015 11:60

    Published on: 25 September 2015

  8. Research

    Sympathetic fibre sprouting in the skin contributes to pain-related behaviour in spared nerve injury and cuff models of neuropathic pain

    Cuff and spared nerve injury (SNI) in the sciatic territory are widely used to model neuropathic pain. Because nociceptive information is first detected in skin, it is important to understand how alterations i...

    Francisney P. Nascimento, Claire Magnussen, Noosha Yousefpour and Alfredo Ribeiro-da-Silva

    Molecular Pain 2015 11:59

    Published on: 17 September 2015

  9. Research

    Pirt contributes to uterine contraction-induced pain in mice

    Uterine contraction-induced pain (UCP) represents a common and severe form of visceral pain. Nerve fibers that innervate uterine tissue express the transient receptor potential vanilloid channel 1 (TRPV1), whi...

    Changming Wang, Zhongli Wang, Yan Yang, Chan Zhu, Guanyi Wu, Guang Yu, Tunyu Jian, Niuniu Yang, Hao Shi, Min Tang, Qian He, Lei Lan, Qin Liu, Yun Guan, Xinzhong Dong, Jinao Duan…

    Molecular Pain 2015 11:57

    Published on: 17 September 2015

  10. Research

    Leukotriene enhances NMDA-induced inward currents in dorsal horn neurons of the rat spinal cord after peripheral nerve injury

    LTB4 is classified as a leukotriene (LT), a group of lipid mediators that are derived from arachidonic acid. It is recognized that leukotrienes are involved in the pathogenesis of many diseases, including peri...

    Yasukuni Kiyoyuki, Wataru Taniguchi, Masamichi Okubo, Hiroki Yamanaka, Kimiko Kobayashi, Naoko Nishio, Terumasa Nakatsuka and Koichi Noguchi

    Molecular Pain 2015 11:53

    Published on: 9 September 2015

  11. Research

    Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain

    Arthritis pain is an important healthcare issue with significant emotional and affective consequences. Here we focus on potentially beneficial effects of activating small-conductance calcium-activated potassiu...

    Jeremy M. Thompson, Guangchen Ji and Volker Neugebauer

    Molecular Pain 2015 11:51

    Published on: 28 August 2015

  12. Short report

    Fatty acid binding protein deletion suppresses inflammatory pain through endocannabinoid/N-acylethanolamine-dependent mechanisms

    Fatty acid binding proteins (FABPs) serve as intracellular carriers that deliver endocannabinoids and N-acylethanolamines to their catabolic enzymes. Inhibition of FABPs reduces endocannabinoid transport and cata...

    Martin Kaczocha, Sherrye T. Glaser, Thomas Maher, Brendan Clavin, John Hamilton, Joseph O’Rourke, Mario Rebecchi, Michelino Puopolo, Yuji Owada and Panayotis K. Thanos

    Molecular Pain 2015 11:52

    Published on: 28 August 2015

  13. Research

    Recruitment of dorsal midbrain catecholaminergic pathways in the recovery from nerve injury evoked disabilities

    The periaqueductal gray region (PAG) is one of several brain areas identified to be vulnerable to structural and functional change following peripheral nerve injury. Sciatic nerve constriction injury (CCI) tri...

    David Mor, James W M Kang, Peter Wyllie, Vignaraja Thirunavukarasu, Hayden Houlton, Paul J Austin and Kevin A Keay

    Molecular Pain 2015 11:50

    Published on: 18 August 2015

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