Figure 7

Capsaicin-sensitivity of αβmeATP-sensitive primary afferents to lamina I A. Example recordings from a lamina I neuron show eEPSCs following 10 sweeps of stimuli in normal bath solution (control), following the application of 100 μM αβmeATP, and washout of the drug (recovery). B. Capsaicin (2 μM) was tested in the same neuron as shown in A. C. The bar graph summarizes capsaicin-induced synaptic failures in 6 lamina I neurons that received ATP/αβmeATP-sensitive primary afferent inputs. D. A summary shows capsaicin-induced reduction of averaged eEPSC amplitude (n = 6). All neurons were recorded from lamina I that received ATP/αβmeATP-sensitive primary afferent inputs.