Figure 1

Effects of σ ₁ R blockade in paclitaxel-induced neuropathic pain behaviors. Effect of paclitaxel + saline and paclitaxel-vehicle + saline on the duration of hind paw licking/biting in the acetone test (a) and on the threshold force for hind paw withdrawal in the electronic Von Frey test (b) in WT and σ₁R-KO mice. Time-courses of the effect of paclitaxel + saline, paclitaxel + BD-1063 (32 mg/kg), and paclitaxel-vehicle + saline in the acetone test (c) and in the electronic Von Frey test (d) in WT mice. The animals were treated once daily from days 1 to 5 with an i.p. injection of paclitaxel (2 mg/kg) or its vehicle (a,b) and with an s.c. injection of BD-1063 or saline 30 min before each paclitaxel dose (c,d). The response was recorded in each animal 3 days before (PRE) and on days 10 and 28 after the start of treatment. Each point and vertical line represents the mean ± SEM of the values obtained in 6–12 animals. Statistically significant differences between WT mice treated with paclitaxel + saline and the rest of the groups on the same day after treatment, **p < 0.01; and between the values on the pretreatment day and the days after treatment, ## p < 0.01 (two-way repeated measures ANOVA followed by Bonferroni test).