Skip to main content
Figure 7 | Molecular Pain

Figure 7

From: Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice

Figure 7

Effect of the pharmacological blockade of the σ 1 R on paclitaxel-induced mitochondrial abnormalities. Effect of treatment with paclitaxel + saline, paclitaxel-vehicle + saline, or paclitaxel + BD-1063 on the percentage of atypical mitochondria in myelinated (a) and unmyelinated (b) fibers of saphenous nerves from WT mice. Each point and vertical line represent the mean ± SEM of the percentage of atypical mitochondria relative to the total number of mitochondria in each type of fiber before treatment (PRE) and at days 10 and 28 posttreatment (n = 3-5 animals per day). Statistically significant differences between WT mice treated with paclitaxel + saline and the rest of the groups on the same day after treatment, **p < 0.01; and between the values on the pretreatment day and the days after treatment, ##p < 0.01 (two-way ANOVA followed by Bonferroni test).

Back to article page

Molecular Pain

ISSN: 1744-8069

Contact us