Figure 4

XE-991 reverses retigabine-induced anticonvulsant activity. (A) The maximal electronic seizures (MES) test was used to determine tonic extensor convulsions in rats exposed to retigabine at 1–100 mg/kg. (B) Retigabine (20 mg/kg)-exposed rats with or without XE-991 (80 μg/site) were tested for anticonvulsant activity via the MES test. Retigabine and XE-991 was administered 30 min and 20 min prior to the MES test, respectively. Numbers on top of each column represent the number of rats in which tonic extensor convulsions were inhibited out of total number (N = 10 and 8, respectively).