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Figure 7 | Molecular Pain

Figure 7

From: Acid evoked thermal hyperalgesia involves peripheral P2Y1 receptor mediated TRPV1 phosphorylation in a rodent model of thrombus induced ischemic pain

Figure 7

The effect of MRS2179 on phosphorylated TRPV1 (pTRPV1) expression in acidic saline injected TIIP (AS-TIIP) rats. TRPV1 and pTRPV1 were detected by using western blots in the hind paw skin of sham + vehicle, AS-TIIP + vehicle and AS-TIIP + MRS2179 (n = 6 in each group, 3 days after surgery and pH 4.0 saline injections). Vehicle and MRS2179 were repetitively injected into the hind paw 30 min before pH 4.0 injection. The level of pTRPV1 expression significantly increased in AS-TIIP rats, and repeated MRS2179 treatment decreased the ratio of pTRPV1 back to the sham control level (*p < 0.05 vs sham + vehicle and # p < 0.05 vs AS-TIIP + vehicle). The level of pTRPV1 expression was normalized against the corresponding total expression of TRPV1. Quantitative analysis of pTRPV1 was calculated as the percent (%) change with respect to the sham group.

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Molecular Pain

ISSN: 1744-8069

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