Table 3 Number of validated mRNA targets of miRNAs that were differentially up- or down-regulated by SNL nerve injury
miRNA identifier | RPM mean HA + LA (sham) | diff-reg abs. value, by subtraction |     No. of verified mRNA targets |       Target genes relevant to pain physiology |
|---|---|---|---|---|
Differentially regulated miRNA | ||||
rno-miR-378b | 49.4 | 0.457 |    0 |  |
rno-miR-322-3p | 30.1 | 0.494 |    2 |      - |
rno-miR-30d-5p | 10,117 | 0.132 |     5 |       Bdnf |
rno-miR-493-3p | 73.1 | 0.316 |    0 |  |
rno-miR-1839-5p | 110.9 | 0,278 |  0 |  |
rno-miR-125b-5p | 3147.6 | 0.265 |     45 |       Tnf, Stat3 |
rno-miR-369-3p | 12.8 | 0.189 |    0 |  |
rno-let-7f-2-3p | 9.9 | 0.567 |    0 |  |
rno-miR-340-3p | 10.2 | 0.561 |    1 |      - |
rno-miR-6331 | 12.8 | 0.467 |    0 |  |
rno-miR-379-5p | 194.7 | 0.278 |      0 |  |
Canonical miRNA of unique sequence isomiR ( diff-reg of isomiR) | ||||
rno-miR-101a-3p | 1735.9 | 0.079 |    28 |      - |
rno-miR-130a-3p | 470.8 | 0.160 |    16 |       Tac1 |
Differential expression at baseline (HA_sham vs. LA_sham) all pools | ||||
rno-miR-184 | 25.2 | 0.550 |    4 |      - |
rno-miR-6325 | 16.4 |    0.114 |      0 |  |