Figure 6

Identification of a subpopulation of chemerin-responsive lamina I NK1R+ neurons. A. Example of a neuron classified as a chemerin responder, because the peak amplitude of the C-fibre eEPSCs falls below the lower 95% prediction band (95% prediction bands designated by the upper and lower grey lines) for at least the final 5 mins of chemerin (100 ng/ml) application. B. Example of a lamina I NK1R+ neuron classified as a chemerin non-responder because the peak amplitude of the C-fibre eEPSCs largely falls within the 95% prediction bands. C. Frequency histogram of the normalised mean eEPSC peak amplitude during the final 5 mins, demonstrating that the distribution of the responses of chemerin responders does not overlap with either the non-responder or vehicle groups.