Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery

Table 1 Locomotor activity during (Day 19) and after (Day 31) chronic drug infusions

Data are mean ± s.e.mean (n = 4-14 per group). All groups received paclitaxel (Taxol) with the exception of the cremophor group receiving vehicle via chronic infusion. Statistical comparisons are denoted with line divisions. All divisions within the table were compared against the cremophor- and paclitaxel-vehicle control animals. WIN-2, WIN55,212-2. Doses of drugs indicated parenthetically are in mg/kg/day s.c. ^* P < 0.05 vs Cremophor-Vehicle, ⁺ P < 0.05 vs. Taxol-WIN55,212-2 (0.5 mg/kg/day s.c.) (ANOVA, Tukey Post Hoc).

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