Figure 3
Enhanced glutamatergic synaptic transmission in the ACC. (A) Sample mEPSCs recording in pyramidal neurons at a holding potential of -70 mV from each group. (B) Left, average mEPSC of events from saline (52 events), vehicle- (67 events), T3- (61 events), and T4- (57 events) treated HT mice; Right, Time constant of mEPSC decay (τ) versus the rising time (10 –90%) in the recordings from saline control (n = 10 slices/5 mice), vehicle- (n = 9 slices/5 mice), T3- (n = 9 slices/5 mice), and T4- (n = 8 slices/5 mice) treated HT mice. (C) Cumulative frequency histogram of the mEPSCs from the slices in each group. (D) Summery of mEPSCs frequency in neurons from saline control, vehicle-, T3-, and T4-treated HT mice. (E) Cumulative amplitude histogram of the mEPSCs from the slices in each group. (F) Summery of mEPSCs amplitude in neurons from control, vehicle-, T3-, and T4-treated HT mice. (D) and (F): Number of recordings from control (n = 11 neurons/5 mice), vehicle- (n = 10 neurons/5 mice), T3- (n = 9 neurons/5 mice), and T4- (n = 8 neurons/5 mice) treated HT mice. * p < 0.05 compared with saline control; # p < 0.05 compared with vehicle-treated HT mice. (G) Sample mEPSCs recording in pyramidal neurons at a holding potential of -70 mV from naïve mice. (H) Summery of mEPSCs frequency (left) amplitude (right) in neurons perfused with saline (n = 8 neurons/4 mice), T3 (n = 10 neurons/4 mice), and T4 (n = 8 neurons/4 mice).