Figure 4

Reduced GABAergic synaptic transmission in the ACC. (A) Sample mIPSCs recording in pyramidal neurons at a holding potential of 0 mV from each group. (B) Left, average mIPSC of events from saline (89 events), vehicle- (97 events), T3- (82 events), and T4- (94 events) treated HT mice; Right, Time constant of mIPSC decay (τ) versus the rising time (10 –90%) in the recordings from saline control (n = 8 slices/5 mice), vehicle- (n = 8 slices/5 mice), T3- (n = 9 slices/5 mice), and T4- (n = 10 slices/5 mice) treated HT HT mice. (C) Cumulative frequency histogram of the mIPSCs from the slices in each group. (D) Summery of mIPSCs frequency in neurons from saline control, vehicle-, T3-, and T4-treated HT mice. (E) Cumulative amplitude histogram of the mIPSCs from the slices in each group. (F) Summery of mIPSCs amplitude in neurons from saline control, vehicle-, T3-, and T4-treated HT mice. (D) and (F): Number of recordings from control (n = 9 neurons/5 mice), vehicle- (n = 11 neurons/5 mice), T3- (n = 10 neurons/5 mice), and T4- (n = 9 neurons/5 mice) treated HT mice. * p < 0.05 compared with control; ^# p < 0.05 compared with vehicle treated-HT mice. (G) Sample mIPSCs recording in pyramidal neurons at a holding potential of 0 mV from naïve mice. (H) Summery of mIPSCs frequency (left) amplitude (right) in neurons perfused with saline (n = 8 neurons/4 mice), T3 (n = 9 neurons/4 mice), and T4 (n = 9 neurons/4 mice).