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Table 2 Electrophysiological characterization of ASIC3 and TRPV1 expression in subsets of muscle afferent dorsal root ganglion neurons

From: Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia

  No. of acid-sensitive neurons in subsets of muscle afferent DRG neurons
Type of acid-induced currents Na V1.8(−), IB4(−) Na V1.8(+), IB4(−) Na V1.8(+), IB4(+)
  (30–40 μm) (30–40 μm) (<30 μm)
ASIC3(+), TRPV1(−) 1 (4%) 4 (13%) 0
ASIC3(+), TRPV1(+) 5 (19%) 5 (17%) 0
ASIC3(−), TRPV1(+) 5 (19%) 2 (7%) 10 (40%)
ASIC3(−), TRPV1(−) 13 (50%) 14 (47%) 6 (24%)
No current 2 (8%) 5 (17%) 9 (36%)
Total 26 30 25