Table 2 Electrophysiological characterization of ASIC3 and TRPV1 expression in subsets of muscle afferent dorsal root ganglion neurons
No. of acid-sensitive neurons in subsets of muscle afferent DRG neurons | |||
|---|---|---|---|
Type of acid-induced currents | Na V1.8(−), IB4(−) | Na V1.8(+), IB4(−) | Na V1.8(+), IB4(+) |
(30–40 μm) | (30–40 μm) | (<30 μm) | |
ASIC3(+), TRPV1(−) | 1 (4%) | 4 (13%) | 0 |
ASIC3(+), TRPV1(+) | 5 (19%) | 5 (17%) | 0 |
ASIC3(−), TRPV1(+) | 5 (19%) | 2 (7%) | 10 (40%) |
ASIC3(−), TRPV1(−) | 13 (50%) | 14 (47%) | 6 (24%) |
No current | 2 (8%) | 5 (17%) | 9 (36%) |
Total | 26 | 30 | 25 |