Figure 1
From: Expression profiling of genes modulated by minocycline in a rat model of neuropathic pain
The effect of minocycline on the development of allodynia and hyperalgesia 7 days after CCI. Influence of preemptive and repeated administration of minocycline (30 mg/kg; i.p.; 16 h and 1 h before CCI and then for 7 days twice daily) on the development of allodynia (A; von Frey test) and hyperalgesia (B; cold plate test) seven days after CCI in rats. The data are presented as the mean ± S.E.M (10–12 rat per group). Allodynia and hyperalgesia were assessed 60 min after drug administration. The inter-group differences were analyzed using an ANOVA and Bonferroni’s multiple comparison test; **p < 0.01 and ***p < 0.001 indicate a significant difference when compared to the control (naïve rats), and ###p < 0.001 indicates a significant difference when compared to the V-CCI rats (ANOVA, Bonferroni’s test). Naive (N), vehicle (V; water for injection), minocycline (MC).