Figure 1

The anti-allodynic effect of IL-10 mediated by the HSV vectors on neuropathic pain induced by HIV gp120 combined with ddC. (A) Mechanical allodynia in rats was shown 1 week post the gp120 application with ddC. The times of gp120 + ddC and HSV vector inoculation were indicated by arrows. QHIL10 resulted in a statistically significant elevation of the mechanical threshold (g) compared with the control vectors (F _(1,12) = 11.996, P < 0.01, repeated measures ANOVA, n = 7). The comparison of differences at individual time points between two groups was shown, *P < 0.05, **P < 0.01 vs. Q0ZHG, two-tailed t test. (B) The AUC in QHIL10 group was significantly higher than that in Q0ZHG, ***P < 0.001, t test, n = 7 rats).