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Figure 2 | Molecular Pain

Figure 2

From: Optimization of a cisplatin model of chemotherapy-induced peripheral neuropathy in mice: use of vitamin C and sodium bicarbonate pretreatments to reduce nephrotoxicity and improve animal health status

Figure 2

Morphine and ibuprofen suppress cisplatin-induced mechanical and cold allodynia with equivalent efficacy in mice pretreated with saline, vitamin C, NaHCO 3 or resveratarol. Mechanical (A) and cold (D) sensitivity did not differ between cisplatin-treated groups receiving different pretreatments (saline, NaHCO3, vitamin C, or resveratrol) that subsequently received vehicle; these groups were pooled into a single pooled/cisplatin-vehicle group. On day 36, morphine (6 mg/kg i.p.) (B, E) and ibuprofen (6 mg/kg i.p.) (C, F) produced time-dependent suppressions of cisplatin-induced mechanical (B, C) and cold (E, F) allodynia. Data are expressed as mean ± s.e.m. (n = 5 per group). *P < 0.0001 for all different (saline, vitamin C, resveratrol or NaHCO3) pretreated/cisplatin groups vs. control/cisplatin-vehicle group (ANOVA, Bonferroni post hoc).

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Molecular Pain

ISSN: 1744-8069

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