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Figure 1 | Molecular Pain

Figure 1

From: Gabapentin reverses central hypersensitivity and suppresses medial prefrontal cortical glucose metabolism in rats with neuropathic pain

Figure 1

Mechanical hypersensitivity after SNI and its reversal by GBP treatment. (A) Mechanical allodynia was tested by von Frey filaments. The 50% withdrawal threshold of the ipsilateral hind paw of rats in the SNI group (n = 12) significantly decreased 3 d after surgery, and remained lower for at least 14 d. The withdrawal threshold of the contralateral hind paw of the SNI group and the bilateral hind paws of the sham group (n = 10) showed no significant changes after surgery. **indicates P < 0.01. Pre: pre-surgery. (B) Paw withdrawal ratio of the 6 g von Frey filament stimulation before the PET scan. In the SNI group (n = 12), the paw withdrawal ratio increased significantly after SNI surgery, and decreased significantly after GBP injection. The sham group (n = 10) showed no significant change in the paw withdrawal ratio. **indicates P < 0.01. Naïve: pre-surgery; SNI/Sham: post-surgery; GBP: post-surgery rats that received a gabapentin injection.

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Molecular Pain

ISSN: 1744-8069

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