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Figure 3 | Molecular Pain

Figure 3

From: Adenylyl cyclase subtype 1 is essential for late-phase long term potentiation and spatial propagation of synaptic responses in the anterior cingulate cortex of adult mice

Figure 3

Basic synaptic transmission and LTP in the ACC with gabapentin application. (A-B) Two mapped figures showed the LTP of the fEPSP slope was induced in the presence of gabapentin (100 μM). The baseline responses (A) were potentiated 3 h after TBS applied on one channel (yellow lightning bolt) (B). Channels with L-LTP and no L-LTP were marked as “a” (green) and “b” (blue), and the TBS-recruited synaptic responses were marked as asterisks. (C) The sample traces and the plotted slope results of one channel showing L-LTP (Ch. 43) and the other without showing L-LTP (Ch. 42) in the superficial layer with gabapentin application. (D) The plotted slope showed the L-LTP of the fEPSP of 8 channels in the superficial layer with gabapentin application. (E) The sample traces and the plotted slope results of one channel showing L-LTP (Ch. 36) and the other without showing L-LTP (Ch. 12) in the deep layer of the same slice with gabapentin application. (F) The plotted slope showed the L-LTP of 11 channels in the deep layer with gabapentin application. (G) The summarized fEPSP slopes of 6 slices/6 mice with gabapentin application. (H) The summarized fEPSP slopes of 6 slices/6 mice showed gabapentin decreased the basic synaptic transmission.

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Molecular Pain

ISSN: 1744-8069

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