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Figure 7 | Molecular Pain

Figure 7

From: Adenylyl cyclase subtype 1 is essential for late-phase long term potentiation and spatial propagation of synaptic responses in the anterior cingulate cortex of adult mice

Figure 7

NB001 and gabapentin did not change the presynaptic release of glutamate. (A) Superimposed samples and summarized results showed that the baseline (pre) of the frequency and amplitude of mEPSCs was not changed by NB001 (0.1 μM, post) application. (B) Gabapentin (100 μM) only decreased the amplitude but not the frequency of the mEPSC. (C-D) NB001 (C) and gabapentin (D) had no effect on the paired pulse ratio recorded with intervals of 35, 50, 75, 100 and 150 ms. (E) Faster MK-801 blockade of NMDA EPSCs. Representative traces showed NMDA EPSCs from 0 to 20 min in the presence of MK-801 (35 μM) with or without NB001 or gabapentin application. NB001 and gabapentin has no effect on the plotted time course of MK-801 blockade of NMDA EPSCs.

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Molecular Pain

ISSN: 1744-8069

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