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Figure 3 | Molecular Pain

Figure 3

From: Cannabinoid receptor 2 agonist attenuates pain related behavior in rats with chronic alcohol/high fat diet induced pancreatitis

Figure 3

Increased Ki67 immunoreactivity in pancreatic tissue and LY3038404 HCl effectively inhibited the expression of Ki67. Pancreas tissue sections are shown. A. Control pancreas tissue has low basal Ki67 expression in the acinar cell nuclei. B. Numerous Ki67 positive cell nuclei are evident in the pancreas of rat with AHF pancreatitis. C. Chronic treatment with LY3038404 HCl effectively blocked Ki67 expression. D. The histogram shows the cell count per mm2 pancreas tissue section. There is a statistically significant difference in Ki67 staining between normal chow fed animals and animals with AHF pancreatitis (One-way ANOVA, Tukey's Multiple Comparison test, n = 6/group, **p < 0.01). LY3038404 HCl treatment effectively reduced Ki67 expression in rats with AHF pancreatitis (n = 6/group, ## p < 0.01). Scale bar = 50 μm.

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Molecular Pain

ISSN: 1744-8069

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