Figure 4
From: TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms
The effect of intrathecal 10 μM SB366791 treatment on the responsiveness to mechanical stimuli after plantar incision. Testing with a range of von Frey filaments after the intrathecal injection of vehicle (15 min before the surgery) indicated the development of postoperative mechanical allodynia (10, 19, 36, 59 and 80 mN) and hyperalgesia (144, 292, 367 mN) on the incised hind paw (n = 6). Intrathecal injection of 10 μM SB366791 (15 min before the surgery) (n = 4) showed only a modest antinociceptive effect on postoperative mechanical allodynia, while mechanical hyperalgesia remained unaffected. *P <0.05, SB366791 injection: incision versus contralateral side; +P <0.05, ++P <0.01, vehicle injection: incision versus contralateral side; #P <0.05 SB366791 versus vehicle injection on the incised hind paw. The time of drug administration is marked by arrow.