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Figure 5 | Molecular Pain

Figure 5

From: Enhanced behavioral responses to cold stimuli following CGRPα sensory neuron ablation are dependent on TRPM8

Figure 5

Preference for warmer temperatures in CGRPα sensory neuron-ablated mice is dependent on TRPM8. Temperature discrimination assay in saline- and DTX-treated (A) Cgrpα-DTR+/- and (B) DTR-Trpm8-/- mice. Floor temperature on each side was maintained at 25°C versus 25°C, 25°C versus 30°C, 20°C versus 30°C, or 30°C versus 40°C. Time spent on each side was measured over a 10 min period and expressed as a percentage relative to the boxed temperature. All values are represented as mean ± SEM. t-tests were used to compare time points between pre-saline/DTX and post-saline/DTX-treated mice. *p < 0.05, ***p < 0005.

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Molecular Pain

ISSN: 1744-8069

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