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Table 5 Associations between P2RX7 gene Tag SNP haplotypes and clinical data

From: Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl

   PPLpre
  Haplotypes Coefficient SE CI z-score p value
1 ACGGAC 13.245 6.576 (0.357, 26.134) 2.014 0.044
2 GCGGAC -0.23 4.252 (-8.563, 8.103) -0.05 0.957
3 GTAAAC -7.275 2.34 (-11.860, -2.689) -3.11 0.002
   Analgesic effect (PPLpost-PPLpre)
   Coefficient SE CI z-score p value
1 ACGGAC 19.452 9.34 (1.146, 37.759) 2.083 0.037
2 GCGGAC -2.966 6.87 (-16.431, 10.499) -0.43 0.666
3 GTAAAC -14.97 4.585 (-23.957, -5.983) -3.27 0.001
   VAS pain score at 24 h
   Coefficient SE CI z-score p value
1 ACGGAC 7.878 4.067 (-0.094, 15.849) 1.937 0.053
2 GCGGAC -10.799 3.523 (-17.705, -3.894) -3.07 0.002
3 GTAAAC 7.434 8.88 (-9.971, 24.839) 0.837 0.402
  1. Haplotype-based associations were tested using linear regression analyses with a recessive model.