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Table 5 Associations between P2RX7 gene Tag SNP haplotypes and clinical data

From: Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl

  

PPLpre

 

Haplotypes

Coefficient

SE

CI

z-score

p value

1

ACGGAC

13.245

6.576

(0.357, 26.134)

2.014

0.044

2

GCGGAC

-0.23

4.252

(-8.563, 8.103)

-0.05

0.957

3

GTAAAC

-7.275

2.34

(-11.860, -2.689)

-3.11

0.002

  

Analgesic effect (PPLpost-PPLpre)

  

Coefficient

SE

CI

z-score

p value

1

ACGGAC

19.452

9.34

(1.146, 37.759)

2.083

0.037

2

GCGGAC

-2.966

6.87

(-16.431, 10.499)

-0.43

0.666

3

GTAAAC

-14.97

4.585

(-23.957, -5.983)

-3.27

0.001

  

VAS pain score at 24 h

  

Coefficient

SE

CI

z-score

p value

1

ACGGAC

7.878

4.067

(-0.094, 15.849)

1.937

0.053

2

GCGGAC

-10.799

3.523

(-17.705, -3.894)

-3.07

0.002

3

GTAAAC

7.434

8.88

(-9.971, 24.839)

0.837

0.402

  1. Haplotype-based associations were tested using linear regression analyses with a recessive model.