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Figure 5 | Molecular Pain

Figure 5

From: Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons

Figure 5

Overexpressing Kv1.2 in the injured DRG mitigates neuropathic pain. Kv1.2 was delivered into the injured DRG through microinjection of AAV5-Kv1.2. AAV5-EGFP was used as a control. (A-C) Behavioral tests show the effect of overexpressing Kv1.2 on the development of spinal nerve ligation (SNL)-induced pain hypersensitivities. Ipsilateral and contralateral paw withdrawal responses to mechanical (A), cold (B), and thermal (C) stimuli at the times shown before and after SNL. n = 5/group. *P < 0.05, **P < 0.01 vs. the ipsilateral side of the AAV5-EGFP-treated group at the corresponding time point. (D-F) Behavioral tests show the effect of overexpressing Kv1.2 on the maintenance of SNL-induced pain hypersensitivities. Ipsilateral and contralateral paw withdrawal responses to mechanical (D), cold (E), and thermal (F) stimuli at the times shown before and after SNL. n = 5/group. *P < 0.05, **P < 0.01 vs. the ipsilateral side of the AAV5-EGFP-treated group at the corresponding time point.

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